DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and TMPRSS7

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_001382436.1	Gene:	TMPRSS7 / 344805	HGNCID:	30846	Length:	843	Species:	Homo sapiens

Alignment Length:	1052	Identity:	179/1052 - (17%)
Similarity:	288/1052 - (27%)	Gaps:	492/1052 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 FLIALLVAG---IFVYVGYTYFRPEPLPDRVFRGRFMVLNDKWSMELANQNSMRFQHKARDYRER 266
            ||..|.|..   :::|:..|    |......|.|.|.:.|.::..|...:.|..|...:|..::.
Human    83 FLFILAVIAWTLLWLYISKT----ESKDAFYFAGMFRITNIEFLPEYRQKESREFLSVSRTVQQV 143

  Fly   267 INLTLRRSDLREAYEGSEILALDGSEDNNNIVVHFNMIF-DPYA-GLVSSGDLLALFHEEMTQPP 329
            |||....|...:.||.| ::|...|.:...::|||.::| .|.| |.:...|.:|...::..|..
Human   144 INLVYTTSAFSKFYEQS-VVADVSSNNKGGLLVHFWIVFVMPRAKGHIFCEDCVAAILKDSIQTS 207

  Fly   330 QQRR----HFANMTVDVASLSIKETTGLIEEPIMSSSPLGGHDETTEPVVTTTPAPPRRCS---- 386
            ...|    ....:.||:.|:.:  ..||..:   .||.:|.               .:.||
Human   208 IINRTSVGSLQGLAVDMDSVVL--NAGLRSD---YSSTIGS---------------DKGCSQYFY 252

  Fly   387 --------PLELS------YCR-----QVGY-------------------NITTYPNLL------ 407
                    |||:|      .|.     .|||                   ::|.|.:||
Human   253 AEHLSLHYPLEISAASGRLMCHFKLVAIVGYLIRLSIKSIQIEADNCVTDSLTIYDSLLPIRSSI 317

  Fly   408 ----------------------------------GHASY-----EQLAEDVIVFREL------VD 427
                                              |..:|     ||..|:.::.:::      :.
Human   318 LYRICEPTRTLMSFVSTNNLMLVTFKSPHIRRLSGIRAYFEVIPEQKCENTVLVKDITGFEGKIS 382

  Fly   428 GECHREAYDFVCRL---LQPPCDTHGSDLQPTPGQICRE----------------YCESFM---- 469
            ...:...|...|:.   .|....|.|..|:.....|.::                ||.|:|
Human   383 SPYYPSYYPPKCKCTWKFQTSLSTLGIALKFYNYSITKKSMKGCEHGWWEINEHMYCGSYMDHQT 447

  Fly   470 ------------AGCGGRLPQR-----FRQF----------FDCER---FPES---TGTQSCHQK 501
                        ..|..||..:     :..:          |.|..   .|::   .|...|..:
Human   448 IFRVPSPLVHIQLQCSSRLSDKPLLAEYGSYNISQPCPVGSFRCSSGLCVPQAQRCDGVNDCFDE 512

  Fly   502 P---HCVSDMQS-NVQS-----PRLCDGYADCPDLSDERSCAF---CSPNALYCGRGRACVPRKA 554
            .   .|||...: |..|     |.:|||:.||.:..||::|..   |:.....||.......:.|
Human   513 SDELFCVSPQPACNTSSFRQHGPLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNA 577

  Fly   555 RCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFHSAGYAVFSEKGVVGKLCAEGLEGD 619
            :|||..|||||:||:.|.                  .||..||.:.:..
Human   578 KCDGTVDCPDGSDEEGCT------------------CSRSSSALHRIIG---------------- 608

  Fly   620 AKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQVLYVGC 684
                             |.:::|
Human   609 -----------------GTDTLE------------------------------------------ 614

  Fly   685 GELRCGVQSALFNAKQHLSLPKMSAPGDWPWLVALFREDIHVCDGTLITQDWVLTTEGCFQGQPR 749
                                      |.|||.|:|.......|..::|:::|:|:...||.|.
Human   615 --------------------------GGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGN-- 651

  Fly   750 ATWMAIVGAVRLSAKAPWTQRRRIIGM-------IKSPVEGSTA-------------ALVRLET- 793
                      |||...|||..   :||       ..|||.....             ||::|..
Human   652 ----------RLSDPTPWTAH---LGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIA 703

  Fly   794 -PVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPSQ 857
             |.:....::|||:|                   |..:|:.
Human   704 WPETLKQLIQPICIP-------------------PTGQRVR------------------------ 725

  Fly   858 EQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTSS 922
                                  .||
Human   726 ----------------------SGE---------------------------------------- 728

  Fly   923 STAARIATKAPILAAVPAAQEQIWTNCNTLGWSRQRDH-------LQRVQLKMGDMAPC-ENVSI 979
                                     .|...||.|:.:.       ||:.::::.|...| ....|
Human   729 -------------------------KCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVSTYGI 768

  Fly   980 ATVNSMCMEATYQKYDCTQEEYSGAPVQCLIPGTNQWALIGVSSWRIACGPTGVERPRMYDKIAS 1044
            .|...:|......|.|..:.: ||.|:.|......:|.|.|:.||....|....  |.:|.::::
Human   769 ITSRMLCAGIMSGKRDACKGD-SGGPLSCRRKSDGKWILTGIVSWGHGSGRPNF--PGVYTRVSN 830

  Fly  1045 NAAWIRETISAI 1056
            ...||.:.:.::
Human   831 FVPWIHKYVPSL 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	26/96 (27%)
		CRD_FZ	384..502	CDD:143549	38/266 (14%)
		PRKCSH-like	<503..>582	CDD:193472	29/87 (33%)
		LDLa	536..571	CDD:238060	14/34 (41%)
		Tryp_SPc	708..>809	CDD:304450	32/122 (26%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143784
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840