DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and CFI

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_001362207.1	Gene:	CFI / 3426	HGNCID:	5394	Length:	601	Species:	Homo sapiens

Alignment Length:	716	Identity:	128/716 - (17%)
Similarity:	200/716 - (27%)	Gaps:	298/716 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 TTTPAPPRRCSPLELSYCRQVGYNI----TTYPN------------LLGHASYEQLAEDVIVFRE 424
            |...|..||..|   :||:|.....    |.:.|            .|.|.:.:   .:.||..:
Human    72 TAVCATNRRSFP---TYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGNTD---SEGIVEVK 130

  Fly   425 LVDGECHREAYDFVCRL---------------LQPPCDTHG----SDLQPTPGQICREYC---ES 467
            |||    ::...|:|:.               .|...||..    |||.....:....:|   |:
Human   131 LVD----QDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTECLHVHCRGLET 191

  Fly   468 FMAGC--GGRLPQRFRQFFDCERFPESTGTQSCHQKP-----HCVSDMQSNVQSPRLCDGYADCP 525
            .:|.|  ..|....::.|.|...:.:..      ..|     .||:.  ..:...:.|||..||.
Human   192 SLAECTFTKRRTMGYQDFADVVCYTQKA------DSPMDDFFQCVNG--KYISQMKACDGINDCG 248

  Fly   526 DLSDERSCAFCSPNALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPY 590
            |.|||..|..|.....:|..| .|:|.:.:|:|:.||..|.||..|.:..         .|.:
Human   249 DQSDELCCKACQGKGFHCKSG-VCIPSQYQCNGEVDCITGEDEVGCAAAR---------HPTI-- 301

  Fly   591 LSRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLND 655
                  .|:|                                  |:..|..||.....|.||..
Human   302 ------QGFA----------------------------------SVTQEETEILTADMDAERRR- 325

  Fly   656 YVRVLDPHAPEISFIRTHCPRRQVLYVGCGELRCGVQSALFNAKQHLSLPKMSAPGDWPWLVALF 720
                          |::..|:          |.|||::.:...::.:...|.:..||.||.||:.
Human   326 --------------IKSLLPK----------LSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIK 366

  Fly   721 REDIHVCDGTLITQDWVLTTEGCFQGQPR---ATWMAIVGAVRLSAKAPWTQRRRIIGMIKSPVE 782
            ......|.|..|...|:||...|.:....   ..|..:|..:....|       ||:
Human   367 DASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLK-------RIV-------- 416

  Fly   783 GSTAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQE 847
                        :.|.|.:                                          :..|
Human   417 ------------IEYVDRI------------------------------------------IFHE 427

  Fly   848 NQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLPDHAPQVNY 912
            |.                                 :|.:|......:..:.||.......|:
Human   428 NY---------------------------------NAGTYQNDIALIEMKKDGNKKDCELPR--- 456

  Fly   913 YSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWT--------NCNTLGWSRQRDHLQRVQLKMG 969
                                .|.|.||      |:        .|...||.|::|:.:...|:.|
Human   457 --------------------SIPACVP------WSPYLFQPNDTCIVSGWGREKDNERVFSLQWG 495

  Fly   970 DMAPCENVSIATVNSMCMEATYQK----YDCTQEEYSG------APVQCLIPGTNQWALIGV-SS 1023
            ::....|.|....|..     |:|    .||.....:|      :.:|...|...|::.:.: ||
Human   496 EVKLISNCSKFYGNRF-----YEKEMECADCCSVAQAGVQWHDLSSLQPPPPRFKQFSCLSLPSS 555

  Fly  1024 W 1024
            |
Human   556 W 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	29/157 (18%)
		PRKCSH-like	<503..>582	CDD:193472	25/78 (32%)
		LDLa	536..571	CDD:238060	12/34 (35%)
		Tryp_SPc	708..>809	CDD:304450	20/103 (19%)
CFI	NP_001362207.1	FIMAC	43..108	CDD:214493	10/38 (26%)
		SR	114..215	CDD:214555	22/107 (21%)
		LDLa	224..256	CDD:238060	11/33 (33%)
		Ldl_recept_a	257..293	CDD:365841	12/36 (33%)
		Tryp_SPc	348..>519	CDD:238113	45/306 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910