DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and fzd7b

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_739569.1	Gene:	fzd7b / 30412	ZFINID:	ZDB-GENE-990415-229	Length:	557	Species:	Danio rerio

Alignment Length:	425	Identity:	89/425 - (20%)
Similarity:	127/425 - (29%)	Gaps:	158/425 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTH 449
            |.|:.:..|..:.||.|..||||||.:.|....:|..|..||..:|.::...|:|.:..|.|...
Zfish    45 CQPISIPLCTDIQYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSQDLKFFLCSMYAPVCTVL 109

  Fly   450 GSDLQPTPGQICREYCESFMAGC-------GGRLPQRFRQFFDCERFPESTGTQSC--------- 498
            ...:.|     ||..||....||       |.:.|:|.|    ||.||.....:.|
Zfish   110 EQAIPP-----CRTLCERARQGCEALMNKFGFQWPERLR----CENFPVHGAGEICVGQNKSDPD 165

  Fly   499 ----HQKPHCVSDMQSNVQSPRLCDGYADCP-DLSDERSCAFCSPNALYCGRGRACVPRKARCDG 558
                :..|:........:.:||....:. || .|:......:....|..||         |.|:.
Zfish   166 VPTTNPTPYIPEPFSPRIHTPRQNQAFT-CPLQLTVPSYLNYHFLGAKNCG---------APCEH 220

  Fly   559 KADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFHSAGYAVFSEK---------GVVGKLCAE 614
            |.                            ||       |...|.|:         |:...||
Zfish   221 KQ----------------------------PY-------GLMYFKEEEVRFGRLWVGIWSILC-- 248

  Fly   615 GLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQV 679
                              |.|      .:|.|..       |:         :...|.|.|.|.:
Zfish   249 ------------------CVS------TLFTVLT-------YL---------VDMRRFHYPERPI 273

  Fly   680 LYV-GCGELRCGVQSALFNAKQHLSLPKMSAPGDWPWLVALFREDIH--VCDGTLITQDWVLTTE 741
            ::: ||..:.....:|.|..:            |....:..||:|..  |..||        ..|
Zfish   274 IFLSGCYFMVAVAYAAGFLLE------------DKVVCIDKFRDDAFKTVAQGT--------KKE 318

  Fly   742 GC--------FQGQPRATWMAIVGAV-RLSAKAPW 767
            ||        |.|...:.|..|:... .|||...|
Zfish   319 GCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKW 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	38/136 (28%)
		PRKCSH-like	<503..>582	CDD:193472	11/79 (14%)
		LDLa	536..571	CDD:238060	6/34 (18%)
		Tryp_SPc	708..>809	CDD:304450	18/71 (25%)
fzd7b	NP_739569.1	CRD_FZ1_like	43..161	CDD:143567	38/124 (31%)
fzd7b	NP_739569.1	Frizzled	228..545	CDD:279827	36/188 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900