DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and TMPRSS11E

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_054777.2	Gene:	TMPRSS11E / 28983	HGNCID:	24465	Length:	423	Species:	Homo sapiens

Alignment Length:	418	Identity:	85/418 - (20%)
Similarity:	123/418 - (29%)	Gaps:	163/418 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   651 ERLNDYV--RVLDPHAPEISFIR--------THCPRRQVLYVGCGELRCGVQSALFNAKQHLSLP 705
            |:|.|.|  ..:|||:.:|..|.        .||         ||..|    |........:...
Human   144 EKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHC---------CGTRR----SKTLGQSLRIVGG 195

  Fly   706 KMSAPGDWPWLVALFREDIHVCDGTLITQDWVLTTEGCFQGQPR-ATWMAIVGAVRLSAKAPWTQ 769
            .....|:|||..:|..:..|.|..|||...|:::...||..... |.|.|..|.....:|.....
Human   196 TEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFGVTIKPSKMKRGL 260

  Fly   770 RRRII-GMIKSPVEGSTAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLE 833
            ||.|: ...|.|......:|..|.:||.|::.|..:|||||
Human   261 RRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDA------------------------ 301

  Fly   834 GQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQEL 898
                                  |.|.|      .||               ..::....||..
Human   302 ----------------------SYEFQ------PGD---------------VMFVTGFGALKN-- 321

  Fly   899 DGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTLGWSRQRDHLQR 963
            |||                                                       .::||::
Human   322 DGY-------------------------------------------------------SQNHLRQ 331

  Fly   964 VQLKMGDMAPCE-----NVSIATVNSMCMEATYQKYDCTQEEYSGAPVQCLIPGTNQ--WALIGV 1021
            .|:.:.|...|.     |.:| |...:|..:...|.|..|.: ||.|   |:....:  |.|.|:
Human   332 AQVTLIDATTCNEPQAYNDAI-TPRMLCAGSLEGKTDACQGD-SGGP---LVSSDARDIWYLAGI 391

  Fly  1022 SSWRIACGPTGVERPRMYDKIASNAAWI 1049
            .||...|...  .:|.:|.::.:...||
Human   392 VSWGDECAKP--NKPGVYTRVTALRDWI 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549
		PRKCSH-like	<503..>582	CDD:193472
		LDLa	536..571	CDD:238060
		Tryp_SPc	708..>809	CDD:304450	32/102 (31%)
TMPRSS11E	NP_054777.2	SEA	51..156	CDD:307516	4/11 (36%)
TMPRSS11E	NP_054777.2	Tryp_SPc	192..420	CDD:238113	70/357 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930