DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and Corin

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_872279.2	Gene:	Corin / 289596	RGDID:	727887	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	749	Identity:	157/749 - (20%)
Similarity:	255/749 - (34%)	Gaps:	250/749 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQ--LAEDVIVFRELVDGECHREAYDFVCRLLQPPCD 447
            |.|:.|..|..:.||:|.|||.|||.:.::  ::.:..:|..||...|::....|.|.:|.|.||
  Rat   521 CEPITLELCMNLPYNLTHYPNYLGHRTQKEASISWESALFPALVQTNCYKYLMFFACTILVPKCD 585

  Fly   448 THGSDLQPTPGQIC---REYCESFMAGCGGRLPQRFRQFFDCERFPEST---------------- 493
            .:.....|....:|   :|.|||.:...|.:.|:.    .||.:|||.:
  Rat   586 VNTGQRVPPCRLLCEHSKERCESVLGIVGLQWPED----TDCSQFPEQSSDNQTCLLPNEDVEEC 646

  Fly   494 --------------GTQSCHQKPHCVSDMQSN------------------VQSPRLCDGYADCPD 526
                          |::.|..:..|..|....                  ::...:|||:.||.|
  Rat   647 SPSHFKCRSGRCVLGSRRCDGQADCDDDSDEENCGCKERDLWECPLNKQCLKHTLICDGFPDCSD 711

  Fly   527 LSDERSCAFCSPNALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYL 591
            ..||::|:||..:.|.|. ...||||...|||..||.|.:||..|::::
  Rat   712 SMDEKNCSFCQDDELECA-NHECVPRDLWCDGWTDCSDSSDEWGCVTLS---------------- 759

  Fly   592 SRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSL------------GYESVEIF 644
            ...:|:.:...........:||:|.:        :|:|:..|:.:            |.|..:..
  Rat   760 KNGNSSSFLTVHRSARDHHVCADGWQ--------ETLSQLACRQMGLGEPSVTELVQGQEGQQWL 816

  Fly   645 DVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQVLYVGCGELRCGVQSALFNAKQHLSLPKMSA 709
            .:.:..|.||...      ..|:...|..||....:.:.|.:..||.:.|....|:.|. .:.|.
  Rat   817 RLHSSWENLNGST------LQELLVHRRSCPSGSEISLLCTKQDCGRRPAARMNKRILG-GRTSR 874

  Fly   710 PGDWPWLVALFREDI-HVCDGTLITQDWVLTTEGCFQGQPRA-TWMAIVGAVRLSAKAPWTQRRR 772
            ||.|||..:|..|.. |:|...||.:.||||...||:|:..| .|..:.|...|...:.:.|.|.
  Rat   875 PGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGREDADVWKVVFGINNLDHPSGFMQTRF 939

  Fly   773 IIGMIKSP-----VEGSTAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERL 832
            :..::..|     |.....::|.|...::.:.:|||:|||.  .|..|:
  Rat   940 VKTILLHPRYSRAVVDYDISVVELSDDINETSYVRPVCLPS--PREFLE---------------- 986

  Fly   833 EGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQE 897

  Rat   987 ----------------------------------------------------------------- 986

  Fly   898 LDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTLGWSRQRD--- 959
                  ||                                         |.|...||....:
  Rat   987 ------PD-----------------------------------------TYCYITGWGHMGNKMP 1004

  Fly   960 -HLQRVQLKMGDMAPCEN-VSIATVNSMCMEATYQK---YDCTQEEYSGAPVQCLIPGTNQWALI 1019
             .||..::::..:..|:: ..:.|:.:..:.|.|:.   ..|..:  ||.|:.|..|| .||.|.
  Rat  1005 FKLQEGEVRIIPLEQCQSYFDMKTITNRMICAGYESGTVDSCMGD--SGGPLVCERPG-GQWTLF 1066

  Fly  1020 GVSSWRIACGPTGVERPRMYDKIASNAAWIRETI 1053
            |::||...|. :.|..|.:|..::....||...|
  Rat  1067 GLTSWGSVCF-SKVLGPGVYSNVSYFVDWIERQI 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	38/151 (25%)
		PRKCSH-like	<503..>582	CDD:193472	28/96 (29%)
		LDLa	536..571	CDD:238060	15/34 (44%)
		Tryp_SPc	708..>809	CDD:304450	35/107 (33%)
Corin	NP_872279.2	DDNN motif	93..96
		CRD_corin_1	200..329	CDD:143554
		LDLa	335..370	CDD:238060
		LDLa	372..406	CDD:238060
		Ldl_recept_a	413..443	CDD:395011
		LDLa	453..480	CDD:238060
		CRD_corin_2	521..641	CDD:143579	36/123 (29%)
		Ldl_recept_a	646..680	CDD:395011	4/33 (12%)
		LDLa	<693..718	CDD:238060	8/24 (33%)
		LDLa	721..755	CDD:238060	15/34 (44%)
		SRCR_2	779..859	CDD:413346	18/93 (19%)
		Tryp_SPc	867..1098	CDD:238113	69/365 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3711
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860