DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and Tmprss15

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_038944148.1	Gene:	Tmprss15 / 288291	RGDID:	1311046	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	987	Identity:	181/987 - (18%)
Similarity:	298/987 - (30%)	Gaps:	421/987 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 PDRVFRGRFMVLNDKWSME------LANQNSMRFQHKARDY-------------------RERIN 268
            |.::.||.|      |..:      .:||.::.|..|:.:|                   .|:||
  Rat   292 PSKILRGSF------WETDPGTIRIFSNQVTVTFLIKSDEYDYIGFNATYSTFNSSEINNYEKIN 350

  Fly   269 LTLRRSDLREAYEGSEILALDGSEDN---NNIVVHFNMIFDPYAGLV---SSGDLLALFHEEMTQ 327
            .|..        :|......|..:||   .|.:..|.....|::...   .||     |:  ::.
  Rat   351 CTFD--------DGFCFWTQDLDDDNEWERNQMARFPCYTGPFSDHTFGNESG-----FY--IST 400

  Fly   328 PPQQRRHFANMTVDVASLSIKETTGLIEEPI-------------------MSSSPLGGHDETTEP 373
            |.:|.  :.:..|.::|||:    |...||:                   :||:      |||:.
  Rat   401 PAEQA--WKSERVGLSSLSL----GFTSEPVCLHFWYYMCCENVYNLNIHVSST------ETTDK 453

  Fly   374 VVTTTPAPPRRCSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFV 438
            :|.....          :|.|...|         |..:..:..|..:||....:..|...|.|
  Rat   454 IVFQRQG----------NYGRNWNY---------GQVTLNETVEFKVVFNAFRNRGCSTIALD-- 497

  Fly   439 CRLLQPPCDTHGSDLQPTPGQICRE--YCESFM---------AGCGGRL----PQRFRQFFDCER 488
                         |:..|.| ||.|  |.|..:         ..|||..    |   ...|....
  Rat   498 -------------DISLTNG-ICSESPYPEPTLVPTPPPEHPTDCGGPFELWEP---NTTFSSPN 545

  Fly   489 FPESTGTQSCHQKPHCVSDMQSNVQSPR--------------------------------LCDGY 521
            ||::...|:     .|:.::  |.||.:                                :..|.
  Rat   546 FPDNYPNQA-----FCIWNL--NAQSGKNIQLHFQEFDLENINDVVEVRDGVKFDSLLLAVYTGR 603

  Fly   522 ADCPDL---SDERSCAF--------------------------CSPNALYCGRGRACVPRKARCD 557
            ....||   ::..:..|                          |..:...|..|. |:|....||
  Rat   604 GPVKDLFSTTNRMTVIFDTDMKNGGKGFKANFTSGYYLGIPQPCQDDEFQCKDGN-CIPMGNLCD 667

  Fly   558 GKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFHS-AGYAVFSEKGVVGKLCAEGLEGDAK 621
            ....|.||:||..|                |.:|:...| .|...|:...:....|||..
  Rat   668 SYQHCSDGSDEAHC----------------VRFLNGTQSNNGLVQFNIHNIWHIACAEPW----- 711

  Fly   622 LVVRQTVSESLCKSLGY----ESVEIFDVQNDT-ERLNDYVRVLDPHAPEISFIRT---HCPRRQ 678
               ...:|..:|..||.    .|:.|....... .|||:        ||..|.|.|   .|.:..
  Rat   712 ---TTQISNEVCHLLGLGSANSSMPILSTGGGPFVRLNE--------APNGSLILTPSLQCSQDS 765

  Fly   679 VLYVGCGELRCGVQSALFNAKQHLSLPKM-----SAPGDWPWLVALFREDIH----VCDGTLITQ 734
            ::.:.|....||.:.    ..|.:. ||:     :..|.|||:|||:..|..    :|..:|::.
  Rat   766 LILLQCNHKSCGEKM----VTQKVG-PKIVGGSDTQAGAWPWVVALYYRDRSGDRLLCGASLVSS 825

  Fly   735 DWVLTTEGCF--QGQPRATWMAIVGA-VRLSAKAPWTQRRRIIGMIKSP-----VEGSTAALVRL 791
            ||:::...|.  :......|.|::|. ::.:..:|...||.:..::.:|     .:.:..|::.|
  Rat   826 DWLVSAAHCVYRRNLDPTRWTAVLGLHMQSNLTSPQVVRRVVDRIVINPHYDKRRKVNDIAMMHL 890

  Fly   792 ETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPS 856
            |..|:|:|:::|||||                                      :|||.|
  Rat   891 EFKVNYTDYIQPICLP--------------------------------------EENQTF----- 912

  Fly   857 QEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTS 921

  Rat   913 ----------------------------------------------------------------- 912

  Fly   922 SSTAARIATKAPILAAVPAAQEQIWTNCNTLGWSRQR-------DHLQRVQLKMGDMAPCE---- 975
              |..|:                    |:..||...:       |.|:...:.:.....|:
  Rat   913 --TPGRM--------------------CSIAGWGYNKINAGSTVDVLKEADVPLVSNEKCQQQLP 955

  Fly   976 NVSIATVNSMCMEATYQK--YDCTQEEYSGAPVQCLIPGTNQWALIGVSSWRIACG-PTGVERPR 1037
            ...| |.:.:|  |.|::  .|..|.: ||.|:.|  ...|:|.|:||:|:.:.|. |   ..|.
  Rat   956 EYDI-TESMLC--AGYEEGGTDSCQGD-SGGPLMC--QENNRWFLVGVTSFGVQCALP---NHPG 1011

  Fly  1038 MYDKIASNAAWI 1049
            :|.:::....||
  Rat  1012 VYARVSQFIEWI 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	23/125 (18%)
		CRD_FZ	384..502	CDD:143549	26/132 (20%)
		PRKCSH-like	<503..>582	CDD:193472	21/139 (15%)
		LDLa	536..571	CDD:238060	12/34 (35%)
		Tryp_SPc	708..>809	CDD:304450	31/112 (28%)
Tmprss15	XP_038944148.1	SEA	54..155	CDD:214554
		LDLa	188..221	CDD:238060
		CUB	229..335	CDD:412131	10/48 (21%)
		MAM	351..507	CDD:395504	40/217 (18%)
		CUB	528..635	CDD:395345	16/116 (14%)
		LDLa	647..681	CDD:238060	12/34 (35%)
		Tryp_SPc	789..1025	CDD:238113	66/374 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840