DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and Fzd9

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_695217.1	Gene:	Fzd9 / 266608	RGDID:	628817	Length:	592	Species:	Rattus norvegicus

Alignment Length:	339	Identity:	78/339 - (23%)
Similarity:	116/339 - (34%)	Gaps:	97/339 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 PAPPRRCSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQ 443
            |||   |..:|:..||.:|||:|..||||||.|..:.|..:..|..||...||.....|:|.|..
  Rat    37 PAP---CQAMEIPMCRGIGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLCSLYA 98

  Fly   444 PPCDTHGSDLQPTPGQICREYCESFMAGCGGRLPQ---RFRQFFDCERFPESTGTQS-CHQ---- 500
            |.|    :|...||...||..||.....|...:.|   .:....||.|.|......: |.:
  Rat    99 PMC----TDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPEN 159

  Fly   501 ------KPHCVSDMQSNVQSPRLCDGYADCPDLSDERSCAFCSPNAL-YCGRGRACVPRKARCDG 558
                  :||....|......|....| ...|......:|.  :|... |..:.|:|.||
  Rat   160 ATAGPTEPHKGLGMLPVAPRPARPPG-DSAPGPGSGGTCD--NPEKFQYVEKSRSCAPR------ 215

  Fly   559 KADCPDGAD------EKD------------CL--SIAPLAADLLQP-------EPLVPYLS---R 593
               |..|.:      :||            |.  :...:...||:|       .|:: :||   .
  Rat   216 ---CGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPERPII-FLSMCYN 276

  Fly   594 FHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLC------------------------- 633
            .:|..:.:.:..|.....|.:  |..|..|:::.:..:.|
  Rat   277 VYSLAFLIRAVAGAQSVACDQ--EAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTW 339

  Fly   634 -----KSLGYESVE 642
                 |..|:|::|
  Rat   340 FLAAGKKWGHEAIE 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	40/131 (31%)
		PRKCSH-like	<503..>582	CDD:193472	17/99 (17%)
		LDLa	536..571	CDD:238060	10/53 (19%)
		Tryp_SPc	708..>809	CDD:304450
Fzd9	NP_695217.1	CRD_FZ9	36..162	CDD:143572	43/131 (33%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000269\|PubMed:12138115	59..173		34/117 (29%)
		7tmF_FZD9	222..543	CDD:320164	20/135 (15%)
		TM helix 1	232..256	CDD:320164	1/23 (4%)
		TM helix 2	265..286	CDD:320164	4/21 (19%)
		TM helix 3	315..337	CDD:320164	0/21 (0%)
		TM helix 4	358..374	CDD:320164
		TM helix 5	396..419	CDD:320164
		TM helix 6	450..472	CDD:320164
		TM helix 7	504..529	CDD:320164
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	533..538
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000269\|PubMed:12138115	555..592
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900