DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and FRZB

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_001454.2	Gene:	FRZB / 2487	HGNCID:	3959	Length:	325	Species:	Homo sapiens

Alignment Length:	407	Identity:	70/407 - (17%)
Similarity:	126/407 - (30%)	Gaps:	142/407 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTH 449
            |.|:.:..|:.:.:|:|..||.|.|::.......:..|..|:...|..:...|:|.:..|.|..
Human    35 CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTI- 98

  Fly   450 GSDLQPTPGQICREYCESFMAGCGGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSDMQSNVQS 514
              |.|..|.:.|:..||....||...| .::|     ..:||:.   :|.:.|
Human    99 --DFQHEPIKPCKSVCERARQGCEPIL-IKYR-----HSWPENL---ACEELP------------ 140

  Fly   515 PRLCDGYADCPDLSDERSCAFCSPNALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLAA 579
                        :.|...|  .||.|:....|             ||.|..:...:|
Human   141 ------------VYDRGVC--ISPEAIVTADG-------------ADFPMDSSNGNC-------- 170

  Fly   580 DLLQPEPLVPYLSRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSLGYESVEIF 644
                                     :|...:.|.                   ||.:.......|
Human   171 -------------------------RGASSERCK-------------------CKPIRATQKTYF 191

  Fly   645 DVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQVLYVGCGELRCGVQSALFNAKQHLSLPKMSA 709
                    .|:|..|:.....||                  :.:|...:|:...|:.|....::.
Human   192 --------RNNYNYVIRAKVKEI------------------KTKCHDVTAVVEVKEILKSSLVNI 230

  Fly   710 PGDWPWLVALFREDIHVCDGTLITQDWVLTTEGCFQGQPRATWMAIVGAV------RLSAKAP-W 767
            |.|   .|.|:.....:|....:.:::::..   ::.:.|:..:.:.|::      ||..|.. |
Human   231 PRD---TVNLYTSSGCLCPPLNVNEEYIIMG---YEDEERSRLLLVEGSIAEKWKDRLGKKVKRW 289

  Fly   768 TQRRRIIGMIKSPVEGS 784
            ..:.|.:|:.||....|
Human   290 DMKLRHLGLSKSDSSNS 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	29/116 (25%)
		PRKCSH-like	<503..>582	CDD:193472	10/78 (13%)
		LDLa	536..571	CDD:238060	7/34 (21%)
		Tryp_SPc	708..>809	CDD:304450	16/84 (19%)
FRZB	NP_001454.2	CRD_SFRP3	32..157	CDD:143550	35/159 (22%)
		NTR_Sfrp3_like	188..297	CDD:239636	22/140 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810