DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and Tmprss7

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_766043.3	Gene:	Tmprss7 / 208171	MGIID:	2686594	Length:	829	Species:	Mus musculus

Alignment Length:	1058	Identity:	188/1058 - (17%)
Similarity:	287/1058 - (27%)	Gaps:	504/1058 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 FLIALLVAG---IFVYVGYTYFRPEPLPDRVFRGRFMVLNDKWSMELANQNSMRFQHKARDYRER 266
            ||..|.|..   :::|:..|    |......|.|.|.:.|.::..|...:.|..|...|:..::.
Mouse    69 FLFILAVTAWTLLWLYISKT----ESKDAFYFVGMFRITNIEFLPEYRQKESREFLSMAKTVQQV 129

  Fly   267 INLTLRRSDLREAYEGSEILALDGSEDNNNIVVHFNMIF-DPYA-GLVSSGDLLALFHEEMTQPP 329
            :||....|...:.|:.| ::|...|.:...::|||.::| .|:| |.:...:.:|...::..|..
Mouse   130 VNLVYTTSAFSKFYKQS-VVADVSSNNKGGLLVHFWIVFVMPHAKGHIFCEECVAAILKDSIQTS 193

  Fly   330 QQRR----HFANMTVDVASLSIKETTGLIEEPIMSSSPLGGHDETTEPVVTTTPAPPRRCS---- 386
            ...|    ....:.||:.|:.:  ..||..:   .||.:|..:               .||
Mouse   194 IINRTSVGSLQGLAVDMDSVVL--NAGLRSD---YSSAVGSDN---------------GCSRYLY 238

  Fly   387 --------PLELS------YCR-----QVGY-------------------NITTYPNLL------ 407
                    |||:|      .|.     .|||                   ::|.|.:||
Mouse   239 ADHLTLRYPLEISATSGQLMCHFKLVAIVGYLIRLSIESIQLEADNCITDSLTVYDSLLPIRSAI 303

  Fly   408 ----------------------------------GHASY-----EQLAEDVIVFREL------VD 427
                                              |..:|     ||..|..|:.:|:      :.
Mouse   304 LYRICEPTRTLMSFVSTNNLMLVILKSPYVRRLAGIRAYFEVIPEQKCESTILVKEINSFEGKIS 368

  Fly   428 GECHREAYDFVCR---LLQPPCDTHGSDLQPTPGQICRE----------------YCESFM---- 469
            ...:...|...|:   ..|....|.|..|:.....|.::                ||.|:|
Mouse   369 SPYYPSYYPPKCKCTWTFQTSLSTLGIALKFYNYSITKKSAKGCEHGWWEINEHMYCGSYMDHET 433

  Fly   470 ------------AGCGGRL---------------------------------PQRFRQFFDCERF 489
                        ..|..||                                 .||.....||  |
Mouse   434 IFRVPSPLVHIQLQCSSRLSDKPLLVEYGGYNISQPCPAGSFRCSSGLCVPQAQRCDGVNDC--F 496

  Fly   490 PESTGTQSCHQKPHCVSDMQSNVQSPRLCDGYADCPDLSDERSCAF---CSPNALYCGRGRACVP 551
            .||........||.|.|. ......|.:|||:.||.|..||::|..   |:.....||.......
Mouse   497 DESDELFCVTVKPACNSS-SFRQHGPLVCDGFRDCEDGQDEQNCTRSIPCTSRTFKCGNDICFRK 560

  Fly   552 RKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFHSAGYAVFSEKGVVGKLCAEGL 616
            :.|:|||..|||||:||:.|                  ..||..|     |..: :||
Mouse   561 QNAQCDGIVDCPDGSDEEGC------------------GCSRSSS-----FLHR-IVG------- 594

  Fly   617 EGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQVLY 681
                                |.:|.|
Mouse   595 --------------------GSDSQE--------------------------------------- 600

  Fly   682 VGCGELRCGVQSALFNAKQHLSLPKMSAPGDWPWLVALFREDIHVCDGTLITQDWVLTTEGCFQG 746
                                         |.|||.|:|.......|..::|:::|:|:...||.|
Mouse   601 -----------------------------GTWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHG 636

  Fly   747 QPRATWMAIVGAVRLSAKAPWTQRRRIIGMIKSPVEGST-----------------------AAL 788
            .            |||...|||..   :||.   |:|:.                       .||
Mouse   637 N------------RLSDPTPWTAH---LGMY---VQGNAKFISPVRRIVVHEYYNSQTFDYDIAL 683

  Fly   789 VRLET--PVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQF 851
            ::|..  |.:....::|||:|.|                        ||.|   ||
Mouse   684 LQLSIAWPETLKQLIQPICIPPA------------------------GQKV---RS--------- 712

  Fly   852 FLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLPDHAPQVNYYSSS 916
                                         ||
Mouse   713 -----------------------------GE---------------------------------- 714

  Fly   917 STVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTLGWSRQRDH-------LQRVQLKMGDMAPC 974
                                           .|...||.|:.:.       ||:.::::.|...|
Mouse   715 -------------------------------KCWVTGWGRRHEADSKGSPVLQQAEVELIDQTVC 748

  Fly   975 -ENVSIATVNSMCMEATYQKYDCTQEEYSGAPVQCLIPGTNQWALIGVSSWRIACGPTGVERPRM 1038
             ....|.|...:|......|.|..:.: ||.|:.|......:|.|.|:.||...||....  |.:
Mouse   749 VSTYGIITSRMLCAGVMSGKSDACKGD-SGGPLSCRRKSDGKWILTGIVSWGHGCGRPNF--PGV 810

  Fly  1039 YDKIASNAAWIRETISAI 1056
            |.:::|...||.:.:.::
Mouse   811 YTRVSSFVPWIHKYVPSL 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	23/96 (24%)
		CRD_FZ	384..502	CDD:143549	42/278 (15%)
		PRKCSH-like	<503..>582	CDD:193472	27/81 (33%)
		LDLa	536..571	CDD:238060	14/34 (41%)
		Tryp_SPc	708..>809	CDD:304450	31/125 (25%)
Tmprss7	NP_766043.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..52
		SEA	94..194	CDD:366610	24/100 (24%)
		CUB	<257..345	CDD:238001	10/87 (11%)
		LDLa	470..504	CDD:238060	7/35 (20%)
		LDLa	545..580	CDD:238060	14/34 (41%)
		Tryp_SPc	591..821	CDD:214473	71/476 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834012
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840