DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and svh-1

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_501379.2	Gene:	svh-1 / 182375	WormBaseID:	WBGene00006620	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	705	Identity:	124/705 - (17%)
Similarity:	203/705 - (28%)	Gaps:	296/705 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 DGECHREAYDFVCRLL---QP--PCDTHGSD-----LQPT-----------PGQICREYCESFMA 470
            |....||....:||:|   .|  ..::|.|:     ||||           |..:.:....|..|
Worm   462 DDNYSREKLSSICRVLGFGDPIYTVESHQSESSLGPLQPTTLHPTNPSFDSPSSVSQMRRTSPSA 526

  Fly   471 GCGGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSDMQSNVQSPRLCDGYADCPDLSDERSCAF 535
            ....|||               ....||.::|:|.|.:.|..:..|                |:.
Worm   527 TLAPRLP---------------AWNLSCLREPNCTSTVISTCEPIR----------------CSH 560

  Fly   536 CSPNALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFH----- 595
            |...|  ||.| :|:.....|:|:.||..|.||..|.:                  :.|.
Worm   561 CQQAA--CGDG-SCIRFDQLCNGQIDCQSGEDEDYCRA------------------NSFRLTNGS 604

  Fly   596 -SAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDYVRV 659
             ::||.....:.....:||:.|.|        .:|.|:|               |..||.::..:
Worm   605 DTSGYLEVLFRSRWEPICADHLNG--------KISNSIC---------------DAMRLGEHGFI 646

  Fly   660 LDPHAPEISFIRTHCP-----RRQVLYVGCGELRCGVQSALFNAKQ-HLSLPKMSA--------- 709
            |..:|...|....:|.     ||.........:.|..|:.:.:|.| .|...:::|
Worm   647 LSTNATISSGYNVNCDVDCSIRRSSSCTRHARISCISQNGMSSASQCGLRYVEVNARDAAKSRIA 711

  Fly   710 ---------PGDWPWLVALFRE--DIHVCDGTLITQDWVLTTEGCFQGQPR-ATWMAIVGAVRLS 762
                     ||.:||..||..:  ..|.|..:::.:..::|...||:...| :::..:||
Worm   712 RVVGGFETVPGAFPWTAALRNKATKAHHCGASILDKTHLITAAHCFEEDERVSSYEVVVG----- 771

  Fly   763 AKAPW-------------TQRRRIIGMIKSPVEGSTAALVRLETP-VSYSDHVRPICLPDALQRR 813
               .|             .||.....:.|. :.....|::.:..| :.::::.:|||||
Worm   772 ---DWDNNQTDGNEQIFYLQRIHFYPLYKD-IFSHDIAILEIPYPGIEFNEYAQPICLP------ 826

  Fly   814 LLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDH 878
                                              ::.|...|.::
Worm   827 ----------------------------------SKDFVYTPGRQ-------------------- 837

  Fly   879 FGGESAASYMPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQE 943

Worm   838 ----------------------------------------------------------------- 837

  Fly   944 QIWTNCNTLGWS----RQRDHLQRVQLKMGDMAPCENVSIATVNSMCMEATYQKY-----DCTQE 999
                 |...||.    |..:.||...:.:.:...|.| |....:||...|....|     |..|.
Worm   838 -----CVVSGWGSMGLRYAERLQAALIPIINRFDCVN-SSQIYSSMSRSAFCAGYLEGGIDSCQG 896

  Fly  1000 EYSGAPVQCLIPGTNQWALIGVSSWRIACGPTGVERPRMYDKIASNAAWIRETIS 1054
            : ||.|..|. .....:.|.||.||...|...  ::|.:|..:|...:||...|:
Worm   897 D-SGGPFACR-REDGAFVLAGVISWGDGCAQK--KQPGIYTMVAPYLSWISAIIN 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	21/95 (22%)
		PRKCSH-like	<503..>582	CDD:193472	19/78 (24%)
		LDLa	536..571	CDD:238060	13/34 (38%)
		Tryp_SPc	708..>809	CDD:304450	26/135 (19%)
svh-1	NP_501379.2	KR	227..306	CDD:214527
		LDLa	320..355	CDD:238060
		PAN_AP_HGF	373..434	CDD:238532
		LDLa	558..590	CDD:197566	12/34 (35%)
		SRCR_2	599..681	CDD:382996	18/104 (17%)
		Tryp_SPc	713..945	CDD:238113	57/375 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24258
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010