DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1632 and Fzd8

DIOPT Version :9

Sequence 1:NP_001245577.1 Gene:CG1632 / 31763 FlyBaseID:FBgn0030027 Length:1056 Species:Drosophila melanogaster
Sequence 2:NP_032084.2 Gene:Fzd8 / 14370 MGIID:108460 Length:685 Species:Mus musculus


Alignment Length:244 Identity:59/244 - (24%)
Similarity:83/244 - (34%) Gaps:74/244 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPC-DT 448
            |..:.:..|:.:|||.|..||...|.:.::...:|..|..||:.:|..:...|:|.:..|.| :.
Mouse    35 CQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLED 99

  Fly   449 HGSDLQPTPGQICREYCESFMAGC-------GGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVS 506
            :...|.|     ||..||...|||       |...|.|.|    |:|.||               
Mouse   100 YKKPLPP-----CRSVCERAKAGCAPLMRQYGFAWPDRMR----CDRLPE--------------- 140

  Fly   507 DMQSNVQSPRLCDGYADCPDLSDERSCAFCSPNAL------------------------------ 541
              |.|..:  ||..|    :.:|..:.|...|..|                              
Mouse   141 --QGNPDT--LCMDY----NRTDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGS 197

  Fly   542 YCGRGRACVPRKARCDGKADCPDGAD---EKDCLSIAPLAADLLQPEPL 587
            ..|.|.|.....:| .|||..|.|..   |..|...||:.:...:..||
Mouse   198 SRGSGDAAAAPPSR-GGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPL 245

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1632NP_001245577.1 SEA 232..327 CDD:279699
CRD_FZ 384..502 CDD:143549 35/124 (28%)
PRKCSH-like <503..>582 CDD:193472 22/111 (20%)
LDLa 536..571 CDD:238060 12/67 (18%)
Tryp_SPc 708..>809 CDD:304450
Fzd8NP_032084.2 CRD_FZ8 31..155 CDD:143570 40/151 (26%)
Palmitate-binding groove 71..78 3/6 (50%)
Wnt-binding 95..100 1/4 (25%)
Wnt-binding 147..152 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..223 13/68 (19%)
7tmF_FZD8 264..616 CDD:320378
TM helix 1 273..298 CDD:320378
TM helix 2 307..328 CDD:320378
TM helix 3 395..417 CDD:320378
TM helix 4 438..454 CDD:320378
TM helix 5 476..499 CDD:320378
TM helix 6 529..554 CDD:320378
TM helix 7 577..602 CDD:320378
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 606..611
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..656
PDZ-binding 683..685
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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