DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1632 and Fzd1

DIOPT Version :9

Sequence 1:NP_001245577.1 Gene:CG1632 / 31763 FlyBaseID:FBgn0030027 Length:1056 Species:Drosophila melanogaster
Sequence 2:NP_067432.2 Gene:Fzd1 / 14362 MGIID:1196625 Length:642 Species:Mus musculus


Alignment Length:264 Identity:66/264 - (25%)
Similarity:91/264 - (34%) Gaps:77/264 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   353 LIEEPIM------SSSPLGGHDETTEPVVTTTPAPPRR------------------CSPLELSYC 393
            |:|.|::      ::..:.|..:...|     |..|::                  |.|:.:..|
Mouse    60 LLEAPLLLGVRAQAAGQVSGPGQQAPP-----PPQPQQSGQQYNGERGISIPDHGYCQPISIPLC 119

  Fly   394 RQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTHGSDLQPTPG 458
            ..:.||.|..||||||.:.|....:|..|..||..:|..|...|:|.:..|.|......|.|   
Mouse   120 TDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALPP--- 181

  Fly   459 QICREYCESFMAGC-------GGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSDMQSNVQSPR 516
              ||..||....||       |.:.|...:    ||:||.....:.      ||....|:..:| 
Mouse   182 --CRSLCERARQGCEALMNKFGFQWPDTLK----CEKFPVHGAGEL------CVGQNTSDKGTP- 233

  Fly   517 LCDGYADCPDLSDERSCAFCSPNALYCGRG-RACVPRKARC--DGKADCPDG-----------AD 567
                   .|.|..|    |.:.|..:.|.| |...|..|..  .||..||..           ..
Mouse   234 -------TPSLLPE----FWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHFLG 287

  Fly   568 EKDC 571
            ||||
Mouse   288 EKDC 291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1632NP_001245577.1 SEA 232..327 CDD:279699
CRD_FZ 384..502 CDD:143549 37/142 (26%)
PRKCSH-like <503..>582 CDD:193472 22/83 (27%)
LDLa 536..571 CDD:238060 12/48 (25%)
Tryp_SPc 708..>809 CDD:304450
Fzd1NP_067432.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..45
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..99 4/27 (15%)
CRD_FZ1 107..233 CDD:143574 40/140 (29%)
7tmF_FZD1 294..641 CDD:320375
TM helix 1 313..338 CDD:320375
TM helix 2 347..368 CDD:320375
TM helix 3 398..424 CDD:320375
TM helix 4 441..457 CDD:320375
TM helix 5 479..508 CDD:320375
TM helix 6 528..555 CDD:320375
TM helix 7 591..616 CDD:320375
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 620..625
PDZ-binding 640..642
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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