DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and AgaP_AGAP007280

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_308537.4	Gene:	AgaP_AGAP007280 / 1269883	VectorBaseID:	AGAP007280	Length:	2275	Species:	Anopheles gambiae

Alignment Length:	873	Identity:	178/873 - (20%)
Similarity:	275/873 - (31%)	Gaps:	294/873 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 HFNMIFDPYAGLVSSGDLLALF----HEEMTQPPQQRRHFANMTVDVASLSIKETTGLIEEPIMS 360
            |..::..|.|..::..|.|...    |.:.|.|....:|...:.:      ..|.|....:.|::
Mosquito   486 HQPLVVGPSAPFLNLCDQLRSAAGNGHLKPTHPGATFQHSPGIPI------TGEATKASSQIIVN 544

  Fly   361 SSPLGGHDETTEPVVTTTPAPPRRCSPLELSYCRQVGYNIT-TYPNLLGHASYEQLAED------ 418
            |:...|:...|  |.....|||....|....: |..|.... .|||..|:..|:...:.
Mosquito   545 SAFGAGYVPNT--VCFYQNAPPVGAQPTAYGF-RPAGSGAPYVYPNAPGYPPYQPHQQQPYHQQH 606

  Fly   419 --------VIVFRELVDGECHREAYDFVCRLLQPPCDTHGSDL---------QPT---------P 457
                    .::...:.....|:..    .|..:.|.|.:|..|         |||         |
Mosquito   607 HHHHPGAGAMINMPVSIQNLHQAG----ARTSELPADQNGPILLCSMMQNVEQPTRHHAGNETHP 667

  Fly   458 GQICREYCESF--MAGCGGRLPQRFRQFFDCERFPESTGTQSCHQKPHCV--------------- 505
            .....|..|:.  |...|..|..|.:....|.|     |:..|.....||
Mosquito   668 EDAEEELDENLDTMFAAGRSLAARAKGRHHCRR-----GSVPCFSSHQCVKRSSWCDSKTDCMDG 727

  Fly   506 SDMQ-----SNVQSPRLCDGYADCPDLSDERSCAFCSPNALYC-----------GRGRACVPRKA 554
            ||..     |.:...:|||||||||...||..|..|...:..|           ..|..|.....
Mosquito   728 SDESACSCVSRLPKRKLCDGYADCPLGMDEMGCFGCEKFSFSCFHTEAEYRSAHRSGSMCYSLLE 792

  Fly   555 RCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFHSAGYAVFSEKGVV-----GK---L 611
            :|||..:|.:..||:||   ..|..||            .|...|:|....||:     ||   :
Mosquito   793 KCDGFDNCLNRKDEQDC---TMLVRDL------------GHYLAYSVPHSTGVLHRNYRGKWYPV 842

  Fly   612 C-------AEGLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDYVRVLDPHAPEIS- 668
            |       .|..|.:...:.|:.:     .|.|:.|:....:   ::|.|..|    |. ||.|
Mosquito   843 CHNPTQWAREACETELGPLDREPL-----LSHGHGSLPGPYI---SQRANSAV----PQ-PEFSE 894

  Fly   669 -----FIRTHCPRRQVLYVGCGELRCGVQ-SALFNAKQHLSLPKM-------------SAPGDWP 714
                 ::...||.     |.||..|...| :|..|.:......:.             :.|..:|
Mosquito   895 ACNGVYVHVKCPA-----VRCGTSRMHEQHAARINVRTRREANESEIVESVRIVGGSHADPEAYP 954

  Fly   715 WLVALFREDIHVCDGTLITQDWVLTTEGCFQGQPRATWMAIVGAVRLSAKAPWTQRRRIIGMI-- 777
            ::|.:||:..:.|.|::..:.|:::...|.....:..:....|.:|..:.||..|..|:..||
Mosquito   955 FIVGIFRDGKYHCGGSIYNEHWIISAAHCCDNFDQHYFEVRSGMLRKRSFAPQVQITRVTHMIVH 1019

  Fly   778 ---KSPVEGSTAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQ 839
               .|.:..:..||:|:|.|..|:..|||||:|
Mosquito  1020 HAYSSSLMANDIALMRVEHPFHYNRWVRPICMP-------------------------------- 1052

  Fly   840 QRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLP 904
            :|.|.:                           |:::..:|        |||
Mosquito  1053 ERHRTT---------------------------DDRDWIWG--------PKA------------- 1069

  Fly   905 DHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTLGWS--RQR----DHLQR 963
                                                     .|.|..:||.  |:|    |||.:
Mosquito  1070 -----------------------------------------GTVCTAIGWGALRERGGAPDHLMQ 1093

  Fly   964 VQLKMGDMAPCENVSIATVNSMCMEATYQKYDCTQEEYSGAPVQCLIPGTN-QWALIGVSSWRIA 1027
            |.:.:  :..|::.|......:|.......:|..|.: ||.|..|...... :|.|.||.|....
Mosquito  1094 VSVPI--LGYCKHKSDRDSLQICAAEEDGGHDACQGD-SGGPFVCQSKSNPFEWYLAGVVSHGEG 1155

  Fly  1028 CGPTGVERPRMYDKIASNAAWIRETISA 1055
            |  .....|.:|.::|....||.|.::|
Mosquito  1156 C--ARAHEPGVYTRVALFIDWIAEKVNA 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	6/30 (20%)
		CRD_FZ	384..502	CDD:143549	28/152 (18%)
		PRKCSH-like	<503..>582	CDD:193472	31/109 (28%)
		LDLa	536..571	CDD:238060	10/45 (22%)
		Tryp_SPc	708..>809	CDD:304450	30/105 (29%)
AgaP_AGAP007280	XP_308537.4	LDLa	698..733	CDD:238060	8/39 (21%)
		Tryp_SPc	941..1175	CDD:214473	65/359 (18%)
		Tryp_SPc	942..1178	CDD:238113	67/361 (19%)
		LDLa	1196..1226	CDD:238060
		LDLa	1510..1541	CDD:238060
		LDLa	1574..1609	CDD:238060
		DUF1986	1774..1887	CDD:286432
		LDLa	1999..2025	CDD:238060
		LDLa	2038..2071	CDD:238060
		LDLa	2107..2142	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910