DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and St14

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_446087.1	Gene:	St14 / 114093	RGDID:	69288	Length:	855	Species:	Rattus norvegicus

Alignment Length:	1066	Identity:	194/1066 - (18%)
Similarity:	302/1066 - (28%)	Gaps:	488/1066 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 AVIAGFLIALLVAGIFVYVGYTYFRPEPLPDRVFRGRFMVLNDKWSMELANQNSMRFQHKARDYR 264
            ||:..||:..|:||:.|:  :.::|...: .:||.|...:.|:.:.....|..|..|...|...:
  Rat    60 AVVFSFLLLSLMAGLLVW--HFHYRNVRI-QKVFNGHLRITNENFLDAYENSTSTEFISLASQVK 121

  Fly   265 ERINLTLRRSDLREAYEGSEILALDGSEDNNNIVVHFNMIFDPYAGLVSSGDLLALFHEEMTQPP 329
            |.:.|..           ||:..| |.....:.|..|           |.|.::|.:..|.:.||
  Rat   122 EALKLMY-----------SEVPVL-GPYHKKSTVTAF-----------SEGSVIAYYWSEFSIPP 163

  Fly   330 QQRRHFANMTVDVASLSIKETTGL------IEEPIMSSSPLGGHDETTEPVVTTTPAPPRRCSPL 388
            .....     ||.| ::::....|      ::..:::|             |...|..||.....
  Rat   164 HLEEE-----VDRA-MAVERVVTLPPRARALKSFVLTS-------------VVAFPIDPRMLQRT 209

  Fly   389 ELSYC--------RQV------GYNITTYPNLLGHASYEQL----AEDV--IVFRELVDGECHRE 433
            :.:.|        |.|      |:..:.||   .||..:.:    |:.|  :.||
  Rat   210 QDNSCSFALHARGRTVTRFTTPGFPNSPYP---AHARCQWVLRGDADSVLSLTFR---------- 261

  Fly   434 AYDFVCRLLQPPCDTHGSDL----------QP-TPGQICREYCESF------------------- 468
            ::|..      |||.|.|||          :| ...::|..:..|:
  Rat   262 SFDVA------PCDGHDSDLVTVYDSLSPMEPHAVVRLCGTFSPSYNLTFLSSQNVFLVTLITNT 320

  Fly   469 ----------------MAGCGGRLPQ----------------------------------RFRQF 483
                            |:.|||.|.:                                  ||:.|
  Rat   321 DRRHPGFEATFFQLPKMSSCGGLLSEAQGTFSSPYYPGHYPPNINCTWNIKVPNNRNVKVRFKLF 385

  Fly   484 F---------DCER-FPESTGTQSCHQK------------------PHCVSD---------MQSN 511
            :         .|.: :.|..|.:.|.::                  .|..:|         ..||
  Rat   386 YLVDPNIPVGSCTKDYVEINGEKFCGERSQFVVSSNSSKITVHFHSDHSYTDTGFLAEYLSYDSN 450

  Fly   512 VQSPRL--------------CDGYADCPDLSDERSC------------AFCSP------------ 538
            ...|.:              |||:|||||.||||.|            .||.|
  Rat   451 DPCPGMFMCKTGRCIRKDLRCDGWADCPDYSDERHCRCNATHQFMCKNQFCKPLFWVCDSVNDCG 515

  Fly   539 ------------NALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYL 591
                        .:..|..|: |:|:..:|:||.||.||:||..|        |.:.......|.
  Rat   516 DGSDEEGCSCPAGSFKCSNGK-CLPQSQQCNGKDDCGDGSDEASC--------DNVNAVSCTKYT 571

  Fly   592 SRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDY 656
            .|                  |..|                ||.:.|
  Rat   572 YR------------------CQNG----------------LCLNKG------------------- 583

  Fly   657 VRVLDPHAPEISFIRTHCPRRQVLYVGCGELRCGVQSALFNAKQHLSLPKMSAPGDWPWLVALFR 721
                   .||       |..::....|..|..|......|..:..:.....:..|:|||.|:|..
  Rat   584 -------NPE-------CDGKKDCSDGSDEKNCDCGLRSFTKQARVVGGTNADEGEWPWQVSLHA 634

  Fly   722 -EDIHVCDGTLITQDWVLTTEGCFQGQ------PRATWMAIVGAVRLSAK-APWTQRRRIIGMIK 778
             ...|:|..:||:.||:::...|||.:      ....|.|.:|.:..|.: |...|..::..:|.
  Rat   635 LGQGHLCGASLISPDWLVSAAHCFQDETIFKYSDHTMWTAFLGLLDQSKRSASGVQEHKLKRIIT 699

  Fly   779 SPVEGS-----TAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVS 838
            .|....     ..||:.||.|..||..||||||||              .:||
  Rat   700 HPSFNDFTFDYDIALLELEKPAEYSTVVRPICLPD--------------NTHV------------ 738

  Fly   839 QQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPL 903
                                                                          :|
  Rat   739 --------------------------------------------------------------FP- 740

  Fly   904 PDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTLGWSRQRDH------LQ 962
                                                 |.:.||..    ||...::.      ||
  Rat   741 -------------------------------------AGKAIWVT----GWGHTKEGGTGALILQ 764

  Fly   963 RVQLKMGDMAPCENV--SIATVNSMCMEATYQKYDCTQEEYSGAPVQCLIPGTNQWALIGVSSWR 1025
            :.::::.:...||.:  ...|...||:.......|..|.: ||.|:.. :....:....||.||.
  Rat   765 KGEIRVINQTTCEELLPQQITPRMMCVGFLSGGVDSCQGD-SGGPLSS-VEKDGRIFQAGVVSWG 827

  Fly  1026 IACGPTGVERPRMYDKIASNAAWIRE 1051
            ..|...  .:|.:|.:|.....||:|
  Rat   828 EGCAQR--NKPGVYTRIPEVRDWIKE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	20/94 (21%)
		CRD_FZ	384..502	CDD:143549	35/245 (14%)
		PRKCSH-like	<503..>582	CDD:193472	36/137 (26%)
		LDLa	536..571	CDD:238060	15/58 (26%)
		Tryp_SPc	708..>809	CDD:304450	37/113 (33%)
St14	NP_446087.1	SEA	88..178	CDD:396113	25/118 (21%)
		CUB	214..332	CDD:238001	23/136 (17%)
		CUB	340..444	CDD:238001	13/103 (13%)
		LDLa	454..486	CDD:238060	13/31 (42%)
		LDLa	492..523	CDD:238060	3/30 (10%)
		LDLa	525..559	CDD:238060	13/34 (38%)
		LDLa	567..602	CDD:238060	12/101 (12%)
		Tryp_SPc	615..852	CDD:238113	69/371 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910