DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and CORIN

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_006578.2	Gene:	CORIN / 10699	HGNCID:	19012	Length:	1042	Species:	Homo sapiens

Alignment Length:	884	Identity:	185/884 - (20%)
Similarity:	302/884 - (34%)	Gaps:	303/884 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 HKARDYRERINLTLRRSDLREAYEGSEILAL----------DGSEDNNNIVVHFNMIFDPYAGLV 312
            |...|..:.:|.:.....|.|...|..|.:.          |||::.|..|:..:         .
Human   366 HDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS---------C 421

  Fly   313 SSGDLLALFHEEMTQPPQQRRHFANMTVDVASLSIKETTGLIEEPIMSSSPLGGHDETTEPVVTT 377
            ..||...|::                                  |.:.|.   |.....:|..:.
Human   422 QEGDQRCLYN----------------------------------PCLDSC---GGSSLCDPNNSL 449

  Fly   378 TPAPPRRCSPLELSYCRQVGYNITTYPNLLGHASYEQ--LAEDVIVFRELVDGECHREAYDFVCR 440
            ...  .:|.|:.|..|..:.||.|:|||..||.:.::  ::.:..:|..||...|::....|.|.
Human   450 NNC--SQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCT 512

  Fly   441 LLQPPCDTHGSDLQPTPGQIC---REYCESFMAGCGGRLPQRFRQFFDCERFP-ESTGTQSC--- 498
            :|.|.||.:..:..|....:|   :|.|||.:...|.:.|:.    .||.:|| |::..|:|
Human   513 ILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPED----TDCSQFPEENSDNQTCLMP 573

  Fly   499 ----------HQK---PHCV---------------SDMQ-------------SNVQSPR---LCD 519
                      |.|   ..||               ||.:             ||.|..:   :||
Human   574 DEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICD 638

  Fly   520 GYADCPDLSDERSCAFCSPNALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLAADLLQP 584
            |:.||||..||::|:||..:.|.|. ..|||.|...|||:|||.|.:||.||::::
Human   639 GFPDCPDYMDEKNCSFCQDDELECA-NHACVSRDLWCDGEADCSDSSDEWDCVTLS--------- 693

  Fly   585 EPLVPYLSRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQND 649
                   ...:|:.:.:.........:||:|.:        :.:|:..||.:|.....:..:..:
Human   694 -------INVNSSSFLMVHRAATEHHVCADGWQ--------EILSQLACKQMGLGEPSVTKLIQE 743

  Fly   650 TERLNDYVRVLDPHA----------PEISFIRTHCPRRQVLYVGCGELRCGVQSALFNAKQHLSL 704
            .|:   ..|.|..|:          .|:......|..|..:.:.|.:..||.:.|....|:.|.
Human   744 QEK---EPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILG- 804

  Fly   705 PKMSAPGDWPWLVALFREDI-HVCDGTLITQDWVLTTEGCFQGQPR-ATWMAIVGAVRLSAKAPW 767
            .:.|.||.|||..:|..|.. |:|...||.:.||||...||:|:.. |.|..::|...|...:.:
Human   805 GRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVF 869

  Fly   768 TQRRRIIGMIKSP-----VEGSTAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVP 827
            .|.|.:..:|..|     |.....::|.|...:|.:.:|||:|||:
Human   870 MQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPN------------------- 915

  Fly   828 VAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAE 892
                                       |.|..:
Human   916 ---------------------------PEQWLE-------------------------------- 921

  Fly   893 ALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTLGWSRQ 957
                       ||                                         |.|...||...
Human   922 -----------PD-----------------------------------------TYCYITGWGHM 934

  Fly   958 RD----HLQRVQLKMGDMAPCEN-VSIATVNSMCMEATYQK---YDCTQEEYSGAPVQCLIPGTN 1014
            .:    .||..::::..:..|:: ..:.|:.:..:.|.|:.   ..|..:  ||.|:.|..|| .
Human   935 GNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGD--SGGPLVCEKPG-G 996

  Fly  1015 QWALIGVSSWRIACGPTGVERPRMYDKIASNAAWIRETI 1053
            :|.|.|::||...|. :.|..|.:|..::....||:..|
Human   997 RWTLFGLTSWGSVCF-SKVLGPGVYSNVSYFVEWIKRQI 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	15/78 (19%)
		CRD_FZ	384..502	CDD:143549	39/139 (28%)
		PRKCSH-like	<503..>582	CDD:193472	36/109 (33%)
		LDLa	536..571	CDD:238060	16/34 (47%)
		Tryp_SPc	708..>809	CDD:304450	37/107 (35%)
CORIN	NP_006578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		DDNN motif	26..29
		CRD_corin_1	135..263	CDD:143554
		LDLa	269..304	CDD:238060
		LDLa	306..340	CDD:238060
		Ldl_recept_a	347..377	CDD:278486	2/10 (20%)
		LDLa	387..414	CDD:238060	5/26 (19%)
		CRD_corin_2	454..575	CDD:143579	37/124 (30%)
		LDLa	580..614	CDD:238060	6/33 (18%)
		LDLa	655..689	CDD:238060	16/34 (47%)
		SR	690..786	CDD:214555	15/122 (12%)
		Tryp_SPc	801..1030	CDD:214473	68/363 (19%)
		Tryp_SPc	802..1033	CDD:238113	70/365 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3729
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860