DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and tmprss2.15

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_031752206.1	Gene:	tmprss2.15 / 101732233	XenbaseID:	XB-GENE-22065943	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	579	Identity:	119/579 - (20%)
Similarity:	197/579 - (34%)	Gaps:	185/579 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 DCERFPESTGTQSCHQKPHCVSDMQSNVQSPRLCDGYADCPDLSDERSCAFCSPNALYCGRGRAC 549
            |||:...:.||        |       |.|.:.|||.:|||:..||.||.......:.||....|
Frog    88 DCEKECGTNGT--------C-------VLSAQWCDGVSDCPNGEDETSCVQTRACQMLCGSSGVC 137

  Fly   550 VPRKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFHSAGYAVFSEKGVVGKLCAE 614
            |.....|||...||:|.||:.|:.:               |...|....|:  ..|.....:|.:
Frog   138 VLYSQWCDGIPQCPNGTDEQTCVRL---------------YGPNFQLQAYS--PAKATWLPVCYD 185

  Fly   615 GLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQV 679
            ....::..:..|.:..|:  |..|:|.::....::...:.....|.......:::..| |....:
Frog   186 EWSDNSGKIACQDIGYSM--SSYYQSSQLLASSSNGYFVLQSSNVTGKMYTNLNYSAT-CASGNM 247

  Fly   680 LYVGCGELRCGVQSALFNAKQHLSLPKMSAPGDWPWLVALFR---EDIHVCDGTLITQDWVLTTE 741
            :.:.|  :.||: |...:::.....|  ::.|||||.|.|.:   ..|::|.|::||..|::|..
Frog   248 VSLRC--ISCGL-STKVDSRIVGGTP--ASVGDWPWQVELLKLVGTSIYLCGGSIITPHWIVTAA 307

  Fly   742 GCFQGQ---PRATWMAIVGAVRLSA--KAPWTQRRRII-GMIKSPVEGSTAALVRLETPVSYSDH 800
            .|..|.   |.| :....|::.:.:  .|.:|..|.:: ....|..:....||::|...:.::.:
Frog   308 HCVYGSTSTPSA-FKVFAGSLTIQSYYSAGYTVERALVHPSYSSYTQIYDVALLKLTAALVFTTN 371

  Fly   801 VRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTE 865
            :||:|||
Frog   372 LRPVCLP---------------------------------------------------------- 378

  Fly   866 NQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAAR--I 928
            |.|                   ||.||       |.|.        :.|...|.....:.::  :
Frog   379 NVG-------------------MPWAE-------GQPC--------WISGWGTTAEGGSISKNLM 409

  Fly   929 ATKAPILAAVPAAQEQIWTNCNTLGWSRQRDHLQRVQLKMGDMAPCENVSIATVNSMCMEATYQK 993
            |...||:::         |.||...                       |....::|..|.|.|..
Frog   410 AASVPIISS---------TTCNQAA-----------------------VYGGAISSTMMCAGYLS 442

  Fly   994 --YDCTQEEYSGAPVQCLIPGTNQ-WALIGVSSWRIACGPTGVERPRMYDKIASNAAWI 1049
              .|..|.: ||.|   |:..||. |.|:|.:||...|  ....:|.:|..:.....||
Frog   443 GGTDTCQGD-SGGP---LVTKTNSLWWLVGDTSWGYGC--ARAYKPGVYGNVTVFIEWI 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	5/16 (31%)
		PRKCSH-like	<503..>582	CDD:193472	26/78 (33%)
		LDLa	536..571	CDD:238060	12/34 (35%)
		Tryp_SPc	708..>809	CDD:304450	31/109 (28%)
tmprss2.15	XP_031752206.1	LDLa	93..121	CDD:238060	13/42 (31%)
		SRCR_2	164..259	CDD:406055	15/102 (15%)
		Tryp_SPc	265..498	CDD:238113	71/364 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910