Protein Alignment ND-75 and NDUFS1

DIOPT Version :10

• Sequence 1: NP_511083.1
• Gene: ND-75 / 31762
• FlyBaseID: FBgn0017566
• Length: 731
• Species: Drosophila melanogaster
• Sequence 2: NP_001186913.1
• Gene: NDUFS1 / 4719
• HGNCID: 7707
• Length: 741
• Species: Homo sapiens
• Alignment Length: 742
• Identity: 453/742 - (61%)
• Similarity: 558/742 - (75%)
• Gaps: 34/742 - (4%)

  Fly     1 MIRAPLVKAL-GALGSPTHQMASRAVRTSAMVAQTPAKAPEKIEVFVDDIPVQVVPGTTVLQAAA 64
            |:|.|:.||| |...||     ...|||:|..|.      ..||||||...|.|.||||||||..
Human    15 MLRIPVRKALVGLSKSP-----KGCVRTTATAAS------NLIEVFVDGQSVMVEPGTTVLQACE 68

  Fly    65 QIGVEIPRFCYHERLAVAGNCRMCLVEVEKSPKPVAACAMPVMKGWRIKTNSDLTRKAREGVMEF 129
            ::|::||||||||||:|||||||||||:||:||.||||||||||||.|.|||:.::|||||||||
Human    69 KVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEF 133

  Fly   130 LLMNHPLDCPICDQGGECDLQDQAMAFGSDRSRFTDINYTGKRAVEDKDIGPLVKTIMTRCIHCT 194
            ||.||||||||||||||||||||:|.||:|||||.:    ||||||||:|||||||||||||.||
Human   134 LLANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLE----GKRAVEDKNIGPLVKTIMTRCIQCT 194

  Fly   195 RCVRFASEIAGVDDLGTTGRGNDMQIGTYVEKLFLTELSGNVIDLCPVGALTNKPYSFVARPWEI 259
            ||:||||||||||||||||||||||:|||:||:|::|||||:||:|||||||:|||:|.|||||.
Human   195 RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWET 259

  Fly   260 RKVSSIDVLDAVGSNIVVSTRTNEVLRILPRENEDVNEEWLADKSRFACDGLKRQRLVAPMVRMP 324
            ||..||||:|||||||||||||.||:|||||.:||:||||::||:|||.||||||||..||||..
Human   260 RKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNE 324

  Fly   325 NGELQAVEWEGALIAVAKAIKA-AGGQIAGISGQLADLEAQVALKDLLNRLGSEVVATEQGF-IA 387
            .|.|....||.||..||..::: .|..:|.|:|.|.|.||.|||||||||:.|:.:.||:.| .|
Human   325 KGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTA 389

  Fly   388 G-GTDNRANYLLNSTIAGLEEADAVLLVGTNPRYEAPLVNTRLRKAYVHNELQIASIGPKIDLSY 451
            | |||.|:|||||:||||:||||.|||||||||:||||.|.|:||:::||:|::|.||..:||:|
Human   390 GAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTY 454

  Fly   452 DHENLGADAALVKDVCSGAHAFSKVLEGAKKPAIIIGADLLERADGAAIHATVAEYCKKLKKP-- 514
            .:::||....:::|:.||:|.||:||:.||||.:::|:..|:|.|||||.|.|:...:|::..
Human   455 TYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSG 519

  Fly   515 ---NWNPFNVLQTNAAQVGALDVGYKAGAQTAVKAQPKVLFLLNADAGKVTREQLPKDCFVVYIG 576
               :|...|:|...|:||.|||:|||.|.:...|..|||||||.||.|.:||:.||||||::|.|
Human   520 VTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQG 584

  Fly   577 SHGDNGASIADAVLPGAAYTEKQGIYVNTEGRPQQTLPGVSPPGMAREDWKILRALSEVVGKPLP 641
            .|||.||.|||.:|||||||||...|||||||.|||...|:|||:|||||||:|||||:.|..||
Human   585 HHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLP 649

  Fly   642 YDNLDELRNRLEDVAPHLTRLGQLEPAGDAGAAGTISKSIGGGAIDIKL----KELRDYFMTDAI 702
            ||.||::|||||:|:|:|.|...:|.|.....|..:||.:....:...|    ..::|::|||:|
Human   650 YDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSI 714

  Fly   703 SRASPTMAKCISAVNKQQRENEAKQSV 729
            ||||.|||||:.||      .|..|:|
Human   715 SRASQTMAKCVKAV------TEGAQAV 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ND-75	NP_511083.1	NuoG	44..632	CDD:273904	392/595 (66%)
		NADH_dhqG_C	671..712	CDD:462757	16/44 (36%)
NDUFS1	NP_001186913.1	NuoG	48..640	CDD:273904	392/595 (66%)
		NADH_dhqG_C	682..724	CDD:462757	16/41 (39%)