DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-75 and Ndufs1

DIOPT Version :9

Sequence 1:	NP_511083.1	Gene:	ND-75 / 31762	FlyBaseID:	FBgn0017566	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001153510.1	Gene:	Ndufs1 / 227197	MGIID:	2443241	Length:	727	Species:	Mus musculus

Alignment Length:	742	Identity:	444/742 - (59%)
Similarity:	548/742 - (73%)	Gaps:	34/742 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIRAPLVKAL-GALGSPTHQMASRAVRTSAMVAQTPAKAPEKIEVFVDDIPVQVVPGTTVLQAAA 64
            |:|.|:.:|| |...||           ...|..|...|...||||||...|.|.||||||||..
Mouse     1 MLRIPIKRALIGLSNSP-----------KGYVRTTGTAASNLIEVFVDGQSVMVEPGTTVLQACE 54

  Fly    65 QIGVEIPRFCYHERLAVAGNCRMCLVEVEKSPKPVAACAMPVMKGWRIKTNSDLTRKAREGVMEF 129
            ::|::||||||||||:|||||||||||:||:||.||||||||||||.|.|||:.::|||||||||
Mouse    55 KVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEF 119

  Fly   130 LLMNHPLDCPICDQGGECDLQDQAMAFGSDRSRFTDINYTGKRAVEDKDIGPLVKTIMTRCIHCT 194
            ||.||||||||||||||||||||:|.||||||||.:    ||||||||:|||||||||||||.||
Mouse   120 LLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLE----GKRAVEDKNIGPLVKTIMTRCIQCT 180

  Fly   195 RCVRFASEIAGVDDLGTTGRGNDMQIGTYVEKLFLTELSGNVIDLCPVGALTNKPYSFVARPWEI 259
            ||:||||||||||||||||||||||:|||:||:|::||||||||:|||||||:|||:|.|||||.
Mouse   181 RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNVIDICPVGALTSKPYAFTARPWET 245

  Fly   260 RKVSSIDVLDAVGSNIVVSTRTNEVLRILPRENEDVNEEWLADKSRFACDGLKRQRLVAPMVRMP 324
            ||..||||:|||||||||||||.||:|||||.:||:||||::||:|||.||||||||..||||..
Mouse   246 RKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNE 310

  Fly   325 NGELQAVEWEGALIAVAKAIK-AAGGQIAGISGQLADLEAQVALKDLLNRLGSEVVATEQGF--I 386
            .|.|....||.||..||..:: ..|..:|.|:|.|.|.||.||||||||::.|:.:.||:.|  .
Mouse   311 KGLLTYTSWEDALSRVAGMLQNFEGNAVAAIAGGLVDAEALVALKDLLNKVDSDNLCTEEIFPTE 375

  Fly   387 AGGTDNRANYLLNSTIAGLEEADAVLLVGTNPRYEAPLVNTRLRKAYVHNELQIASIGPKIDLSY 451
            ..|||.|:|||||:||||:||||.|||||||||:||||.|.|:||:::||:|::|.||..:||:|
Mouse   376 GAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTY 440

  Fly   452 DHENLGADAALVKDVCSGAHAFSKVLEGAKKPAIIIGADLLERADGAAIHATVAEYCKKLK---- 512
            .:::||....:::|:.||.|:|.:||:.||||.:::|:..|:|.|||||...|:...:|::
Mouse   441 RYDHLGDSPKILQDIASGRHSFCEVLKDAKKPMVVLGSSALQRDDGAAILVAVSNMVQKIRVTTG 505

  Fly   513 -KPNWNPFNVLQTNAAQVGALDVGYKAGAQTAVKAQPKVLFLLNADAGKVTREQLPKDCFVVYIG 576
             ...|...|:|...|:||.|||:|||.|.:...|..||:||||.||.|.:||:.||||||:||.|
Mouse   506 VAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKMLFLLGADGGCITRQDLPKDCFIVYQG 570

  Fly   577 SHGDNGASIADAVLPGAAYTEKQGIYVNTEGRPQQTLPGVSPPGMAREDWKILRALSEVVGKPLP 641
            .|||.||.:||.:|||||||||...|||||||.|||...|:|||:|||||||:|||||:.|..||
Mouse   571 HHGDVGAPMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLP 635

  Fly   642 YDNLDELRNRLEDVAPHLTRLGQLEPAGDAGAAGTISKSIGGGAIDIKL----KELRDYFMTDAI 702
            ||.||::|||||:|:|:|.|...:|.......|..::|.:....:...|    ..::|::|||:|
Mouse   636 YDTLDQVRNRLEEVSPNLVRYDDIEETNYFQQASELAKLVNQEVLADPLVPPQLTIKDFYMTDSI 700

  Fly   703 SRASPTMAKCISAVNKQQRENEAKQSV 729
            ||||.|||||:.||      .|..|:|
Mouse   701 SRASQTMAKCVKAV------TEGAQAV 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-75	NP_511083.1	Fer2_4	40..116	CDD:290244	56/75 (75%)
		PRK09130	42..722	CDD:236387	430/691 (62%)
		NADH-G_4Fe-4S_3	123..163	CDD:214918	36/39 (92%)
		MopB_Res-Cmplx1_Nad11	263..636	CDD:239174	217/380 (57%)
		NADH_dhqG_C	671..712	CDD:286416	15/44 (34%)
Ndufs1	NP_001153510.1	PRK09130	31..723	CDD:236387	433/701 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832323
Domainoid	1	1.000	343	1.000	Domainoid score	I1063
eggNOG	1	0.900	-	-		E1_COG1034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3670
Inparanoid	1	1.050	869	1.000	Inparanoid score	I416
Isobase	1	0.950	-	0	Normalized mean entropy	S2304
OMA	1	1.010	-	-		QHG54878
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006681
OrthoInspector	1	1.000	-	-		oto94200
orthoMCL	1	0.900	-	-		OOG6_101681
Panther	1	1.100	-	-	LDO	PTHR11615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4072
SonicParanoid	1	1.000	-	-		X4888
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740