DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and IRC15

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_015308.1	Gene:	IRC15 / 856090	SGDID:	S000005938	Length:	499	Species:	Saccharomyces cerevisiae

Alignment Length:	507	Identity:	115/507 - (22%)
Similarity:	209/507 - (41%)	Gaps:	63/507 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 YDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQASLL 179
            ||::|||.|..|...|.:|...|...||:|         .:..:||..:..|.:|.|.:...|.|
Yeast    18 YDVLVIGCGPGGFTAAMQASQAGLLTACVD---------QRASLGGAYLVDGAVPSKTLLYESYL 73

  Fly   180 GEAVHEAAAYGWNVDEK------IKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGSFV 238
            ...:.:...    ::::      .|.|......:::::|:.:..|.:.:|....|....|..:|.
Yeast    74 YRLLQQQEL----IEQRGTRLFPAKFDMQAAQSALKHNIEELGNVYKRELSKNNVTVYKGTAAFK 134

  Fly   239 DSHTL-LAKLKSGERTITAQTFVIAVGGRPRYPDIPG-AVEYG--ITSDDLFSLDREPGKTLVVG 299
            |.|.: :|:.......:.|:..|:|.|.  .....|| |::..  |:||...|||..|.:..::|
Yeast   135 DPHHVEIAQRGMKPFIVEAKYIVVATGS--AVIQCPGVAIDNDKIISSDKALSLDYIPSRFTIMG 197

  Fly   300 AGYIGLECAGFLKGLGYEPTVM-VRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEKQDD 363
            .|.||||.|.....||...|:: .:|.:.:..|.::|......::.:||.||..|.....|....
Yeast   198 GGTIGLEIACIFNNLGSRVTIVESQSEICQNMDNELASATKTLLQCQGIAFLLDTRVQLAEADAA 262

  Fly   364 GKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQK--DKIPVDSQEATNVANI 426
            |:|.:...|..:.:......|.::.:|||:.|:..|::.:.|:..:.  :.:.|.:|......:|
Yeast   263 GQLNITLLNKVSKKTYVHHCDVLMVSIGRRPLLKGLDISSIGLDERDFVENVDVQTQSLLKYPHI 327

  Fly   427 YAVGDIIYGKPELTPVAVLAGRLLARRLY-----GGSTQRMDYKDVATTVFTPLEYACVGLSEED 486
            ..:||:..|     |:..|.....|.|..     .||....:.......::...:...||.:||.
Yeast   328 KPIGDVTLG-----PMLALKAEEQAIRAIQSIGCTGSDGTSNCGFPPNVLYCQPQIGWVGYTEEG 387

  Fly   487 AVKQFGADEIEVFHGYYKPTEFFIPQKSVRY-------------CYLKAVAERHGDQRVYGLHYI 538
            ..|.    .|.    |.|....|  .::|||             .::|.:.:.. |.::.|:|.|
Yeast   388 LAKA----RIP----YQKGRVLF--SQNVRYNTLLPREENTTVSPFIKVLIDSR-DMKILGVHMI 441

  Fly   539 GPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTR-LAITKRSGLDP 589
            ...|.|::...:.|:..|||.:.:......||:.:|.|.: :.:...:|..|
Yeast   442 NDDANELLSQASMAVSLGLTAHDVCKVPFPHPSLSESFKQAVQLAMANGTSP 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	115/507 (23%)
		NADB_Rossmann	115..>150	CDD:304358	13/34 (38%)
		Pyr_redox	294..368	CDD:278498	21/74 (28%)
		Pyr_redox_dim	468..577	CDD:280934	26/121 (21%)
IRC15	NP_015308.1	Lpd	18..482	CDD:224169	113/494 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810