DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trxr-1 and GLR1

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_015234.1	Gene:	GLR1 / 856014	SGDID:	S000006012	Length:	483	Species:	Saccharomyces cerevisiae

Alignment Length:	504	Identity:	174/504 - (34%)
Similarity:	269/504 - (53%)	Gaps:	62/504 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGC 167
            :|.|||....|||  :||||||.|:|.|:.|...||:...::          ...:|||||||||
Yeast    14 IRTMSTNTKHYDY--LVIGGGSGGVASARRAASYGAKTLLVE----------AKALGGTCVNVGC 66

  Fly   168 IPKKLMHQASLLGEAVHEAAAYGWNVD-----EKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKK 227
            :|||:|..||.|...|..|..||...:     |.:..:|.:..|....::..:|.:.:.:|..:|
Yeast    67 VPKKVMWYASDLATRVSHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEK 131

  Fly   228 VEYINGLGSF-VDSHTLLAKLKSGERTITAQTFVIAVGGRPRYPD-IPGAVEYGITSDDLFSLDR 290
            |:.:.|...| .|.:..:.|..:.....:|...::|.||:..:|: ||| .|.|..||..|.|:.
Yeast   132 VDVVFGWARFNKDGNVEVQKRDNTTEVYSANHILVATGGKAIFPENIPG-FELGTDSDGFFRLEE 195

  Fly   291 EPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEERGIPFLRKTV 354
            :|.|.:||||||||:|.||...|||.|..:::| ..|||.||:.:...:.....:.||
Yeast   196 QPKKVVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNTITDHYVKEGI------- 253

  Fly   355 PLSVEKQDDGKLLVKYKNVET---------GEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQK 410
              :|.|.  .|::...|||||         .:..:|| |.::|.||||..: .:...|.|:.:..
Yeast   254 --NVHKL--SKIVKVEKNVETDKLKIHMNDSKSIDDV-DELIWTIGRKSHL-GMGSENVGIKLNS 312

  Fly   411 -DKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGS---TQRMDYKDVATTV 471
             |:|..|..:.|||.|||::||:: ||.||||||:.|||.|:.||:|..   ..::||::|.:.:
Yeast   313 HDQIIADEYQNTNVPNIYSLGDVV-GKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENVPSVI 376

  Fly   472 FTPLEYACVGLSEEDAVKQFGADEIEVFHG-----YYKPTEFFIPQKS-VRYCYLKAVAERHGDQ 530
            |:..|...:|:||::|::::|.:.|:|::.     ||.    .:.:|| .||..:.|    ..::
Yeast   377 FSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYA----MLSEKSPTRYKIVCA----GPNE 433

  Fly   531 RVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 579
            :|.|||.:|..:.|::|||..|:|.|.|.....|.|.||||:|||...:
Yeast   434 KVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTM 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	170/494 (34%)
		NADB_Rossmann	115..>150	CDD:304358	13/34 (38%)
		Pyr_redox	294..368	CDD:278498	27/74 (36%)
		Pyr_redox_dim	468..577	CDD:280934	38/114 (33%)
GLR1	NP_015234.1	gluta_reduc_1	22..483	CDD:273614	170/496 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I738
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I652
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm46525
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
TreeFam	0	0.000	Not matched by this tool.
	8	7.890