DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and txnrd2.2

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001340325.1	Gene:	txnrd2.2 / 798259	ZFINID:	ZDB-GENE-040914-66	Length:	517	Species:	Danio rerio

Alignment Length:	488	Identity:	278/488 - (56%)
Similarity:	352/488 - (72%)	Gaps:	5/488 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 GSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQ 175
            |.:||||:||||||.||||:|||...|.:||.||:|:|: ..|||||:|||||||||||||||||
Zfish    29 GKFDYDLVVIGGGSGGLACSKEAAQLGQKVAVLDYVEPS-LKGTKWGLGGTCVNVGCIPKKLMHQ 92

  Fly   176 ASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGSFVDS 240
            |:|||.||.:|..|||.:.|.:..||..:.::||||::|:||..||.|:||||:|:|..|:.:|.
Zfish    93 AALLGTAVKDARKYGWQIPETLSHDWPTMAEAVQNHVRSLNWGHRVQLQDKKVKYLNMKGTLLDK 157

  Fly   241 HTLLAKLKSG-ERTITAQTFVIAVGGRPRYP-DIPGAVEYGITSDDLFSLDREPGKTLVVGAGYI 303
            ||:.|....| |.|:||:..::|.||||:|| .:|||:|:||||||:|.|...|.|||::||.|:
Zfish   158 HTVRAVNAQGKEMTVTARNILLATGGRPKYPTHVPGAMEFGITSDDIFWLKESPKKTLIIGASYV 222

  Fly   304 GLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEKQDDGKLLV 368
            .|||||||.|:|.:.:||||||.||||||||:.||...||..|..|..|..|.||||...|.|.|
Zfish   223 SLECAGFLTGIGLDTSVMVRSIALRGFDQQMSGLVTDYMETYGTKFHWKCTPKSVEKLPSGHLQV 287

  Fly   369 KYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQKD--KIPVDSQEATNVANIYAVGD 431
            .:.::.|.||.:|.:::||||:||......|||...||.:.|:  ||.|.:.|||:|.||:|:||
Zfish   288 TWMDLNTKEEHQDTFNSVLWAVGRAPETKTLNLEKVGVKINKETGKIIVAADEATSVPNIFAIGD 352

  Fly   432 IIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEI 496
            |..|:|||||.|:.||:|||.||.|.||:.|:|::|||||||||||.|||||||:|.::.|.|:|
Zfish   353 IGEGRPELTPTAIKAGKLLAHRLAGRSTELMNYENVATTVFTPLEYGCVGLSEEEAERRHGKDQI 417

  Fly   497 EVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINT 561
            ||:|.:|||.||.:.::....||:|.|..|.|||||.|||:.||.||||.||||...:.|||...
Zfish   418 EVYHAFYKPLEFTVAERDATQCYIKVVCLREGDQRVLGLHFTGPNAGEVTQGFALGFQCGLTYEH 482

  Fly   562 LINTVGIHPTTAEEFTRLAITKRSGLDPTPASC 594
            |.||||||||.|||.|:|.||||||||.|...|
Zfish   483 LRNTVGIHPTCAEELTKLNITKRSGLDATVTGC 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	277/486 (57%)
		NADB_Rossmann	115..>150	CDD:304358	23/34 (68%)
		Pyr_redox	294..368	CDD:278498	43/73 (59%)
		Pyr_redox_dim	468..577	CDD:280934	67/108 (62%)
txnrd2.2	NP_001340325.1	Pyr_redox_dim	31..517	CDD:332164	277/486 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I864
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	556	1.000	Inparanoid score	I1082
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm24606
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	1	1.100	-	-	LDO	PTHR48105
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870