DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and TXNRD1

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001087240.1	Gene:	TXNRD1 / 7296	HGNCID:	12437	Length:	649	Species:	Homo sapiens

Alignment Length:	489	Identity:	273/489 - (55%)
Similarity:	340/489 - (69%)	Gaps:	7/489 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQA 176
            |||||||:|||||.|||.||||...|.:|..||||.||| |||:||:||||||||||||||||||
Human   160 SYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTP-LGTRWGLGGTCVNVGCIPKKLMHQA 223

  Fly   177 SLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGSFVDSH 241
            :|||:|:.::..|||.|:|.:|.||.:::::|||||.|:||..||.||:|||.|.|..|.|:..|
Human   224 ALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPH 288

  Fly   242 TLLAKLKSG-ERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDREPGKTLVVGAGYIGL 305
            .:.|....| |:..:|:.|:||.|.||||..|||..||.|:|||||||...|||||||||.|:.|
Human   289 RIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVAL 353

  Fly   306 ECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEKQD---DGKLL 367
            ||||||.|:|.:.|||||||:||||||.||..:...|||.||.|:|:.||:.||:.:   .|:|.
Human   354 ECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLR 418

  Fly   368 VKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQK--DKIPVDSQEATNVANIYAVG 430
            |..::..:.|..|..|:||:.||||......:.|...||.:.:  .||||..:|.|||..|||:|
Human   419 VVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIG 483

  Fly   431 DIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFGADE 495
            ||:..|.||||||:.||||||:|||.|||.:.||::|.|||||||||...|||||.||::||.:.
Human   484 DILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEEN 548

  Fly   496 IEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTIN 560
            |||:|.|:.|.|:.||.:....||.|.:.....::||.|.|.:||.||||.||||||||.|||..
Human   549 IEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKK 613

  Fly   561 TLINTVGIHPTTAEEFTRLAITKRSGLDPTPASC 594
            .|.:|:||||..||.||.|::|||||.....|.|
Human   614 QLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGC 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	272/488 (56%)
		NADB_Rossmann	115..>150	CDD:304358	23/34 (68%)
		Pyr_redox	294..368	CDD:278498	45/76 (59%)
		Pyr_redox_dim	468..577	CDD:280934	59/108 (55%)
TXNRD1	NP_001087240.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		GRX_GRXh_1_2_like	68..148	CDD:239511
		TGR	161..649	CDD:273624	272/488 (56%)
		Pyr_redox	342..418	CDD:278498	44/75 (59%)
		Pyr_redox_dim	521..631	CDD:280934	60/109 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5308
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S1111
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.680