DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and gsr

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_005169649.1	Gene:	gsr / 553575	ZFINID:	ZDB-GENE-050522-116	Length:	500	Species:	Danio rerio

Alignment Length:	488	Identity:	165/488 - (33%)
Similarity:	260/488 - (53%)	Gaps:	30/488 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCI 168
            |.|:: |....:|.:|:||||.|||.|:.|...||..|.::..:          :|||||||||:
Zfish    30 RSMAS-GSVSRFDFLVVGGGSGGLAGARRAAELGATTAVIESHR----------LGGTCVNVGCV 83

  Fly   169 PKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYING 233
            |||:|...|...|.:|:...||:. ..|....|..:......::..:|.:.|.:|...|:|:|:|
Zfish    84 PKKVMWNTSTHAEYLHDHEDYGFE-GAKAHFSWQIIKHKRDAYVSRLNQIYRSNLEKGKIEFIHG 147

  Fly   234 LGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRP---RYPDIPGAVEYGITSDDLFSLDREPGKT 295
            ...|.|......::..  :..||...:|:.||.|   ...|:||: ..|||||..|.|:..|.::
Zfish   148 YARFTDDPEPTVEVNG--KKYTATHILISTGGHPSTVSEDDVPGS-SLGITSDGFFELESCPKRS 209

  Fly   296 LVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVE 359
            ::||||||.:|.||.|..||.:.::::| ..|||.||..::......::..||...:.|...||:
Zfish   210 VIVGAGYIAVEMAGILSTLGSKTSIIIRQGGVLRNFDALISSNCTKELQNNGIDLRKNTQVKSVK 274

  Fly   360 KQDDGKLLVKYKNVETGEEAEDVYDTV------LWAIGRKGLVDDLNLPNAGVTV-QKDKIPVDS 417
            |...|..:.........:::::.:||:      ||||||:.....|||...||.: ::..|.||.
Zfish   275 KNGKGLSITLVTKDPDDKDSQEKFDTINDVDCLLWAIGREPNTAGLNLSQIGVKLDERGHIVVDE 339

  Fly   418 QEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLY-GGSTQRMDYKDVATTVFTPLEYACVG 481
            .:.|:...:|||||:. |:..|||||:.|||.||.||: |.:..::||.::.|.||:......||
Zfish   340 FQNTSRPGVYAVGDVC-GRALLTPVAIAAGRKLAHRLFEGKADSKVDYNNIPTVVFSHPPIGTVG 403

  Fly   482 LSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVI 546
            |:|::|||.:|.|:::|:...:.|..:.|..:..: |.:|.|.... :::|.|||..|....|::
Zfish   404 LTEDEAVKTYGKDKVKVYTTSFTPMYYAITTRKSQ-CIMKLVCAGE-NEKVVGLHMQGFGCDEML 466

  Fly   547 QGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 579
            ||||.|:..|.|......|:.||||::||...|
Zfish   467 QGFAVAVNMGATKADFDRTIAIHPTSSEELVTL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	162/479 (34%)
		NADB_Rossmann	115..>150	CDD:304358	14/34 (41%)
		Pyr_redox	294..368	CDD:278498	25/74 (34%)
		Pyr_redox_dim	468..577	CDD:280934	38/108 (35%)
gsr	XP_005169649.1	gluta_reduc_1	56..500	CDD:273614	152/461 (33%)
		Pyr_redox	208..284	CDD:278498	25/75 (33%)
		Pyr_redox_dim	390..498	CDD:280934	38/109 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850