Protein Alignment Trxr-1 and Txnrd1

DIOPT Version :9

• Sequence 1: NP_727251.1
• Gene: Trxr-1 / 31760
• FlyBaseID: FBgn0020653
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001035988.1
• Gene: Txnrd1 / 50493
• MGIID: 1354175
• Length: 613
• Species: Mus musculus
• Alignment Length: 562
• Identity: 285/562 - (50%)
• Similarity: 360/562 - (64%)
• Gaps: 28/562 - (4%)

  Fly    59 LTGQRGSRDSTGATGGNAPAGSGAGAP------PPFQHPHCDRAAMYAQ--------PVRKMSTK 109
            |.|.||:...........|:.|....|      ||...|. .|.....|        .::|:.|.
Mouse    52 LRGPRGAVLPASRPSKTLPSSSQTPCPTDPCICPPPSTPD-SRQEKNTQSELPNKKGQLQKLPTM 115

  Fly   110 G------GSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCI 168
            .      ||||:|||:|||||.|||.||||.....:|..||||.||| |||:||:||||||||||
Mouse   116 NGSKDPPGSYDFDLIIIGGGSGGLAAAKEAAKFDKKVLVLDFVTPTP-LGTRWGLGGTCVNVGCI 179

  Fly   169 PKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYING 233
            ||||||||:|||:|:.::..|||.|::.:|.||.|:.:|||:||.|:||..||.||:|||.|.|.
Mouse   180 PKKLMHQAALLGQALKDSRNYGWKVEDTVKHDWEKMTESVQSHIGSLNWGYRVALREKKVVYENA 244

  Fly   234 LGSFVDSHTLLAKLKSG-ERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDREPGKTLV 297
            .|.|:..|.::|....| |:..:|:.|:||.|.||||..|||..||.|:|||||||...||||||
Mouse   245 YGRFIGPHRIVATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLV 309

  Fly   298 VGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEKQD 362
            |||.|:.|||||||.|:|.:.|||||||:||||||.||..:...|||.||.|:|:.||..:|:.:
Mouse   310 VGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPTKIEQIE 374

  Fly   363 ---DGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQK--DKIPVDSQEATN 422
               .|:|.|..::..:.|..|..::|||.|:||......:.|...||.:.:  .||||..:|.||
Mouse   375 AGTPGRLRVTAQSTNSEETIEGEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQTN 439

  Fly   423 VANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEEDA 487
            |..|||:|||:.||.||||||:.||||||:||||||..:.||.:|.|||||||||.|.|||||.|
Mouse   440 VPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSNVKCDYDNVPTTVFTPLEYGCCGLSEEKA 504

  Fly   488 VKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAA 552
            |::||.:.|||:|.::.|.|:.:|.:....||.|.:.....|:||.|.|.:||.||||.||||||
Mouse   505 VEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKIICNLKDDERVVGFHVLGPNAGEVTQGFAAA 569

  Fly   553 LKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLDPTPASC 594
            ||.|||...|.:|:||||..||.||.|::|||||.|...:.|
Mouse   570 LKCGLTKQQLDSTIGIHPVCAEIFTTLSVTKRSGGDILQSGC 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	269/488 (55%)
		NADB_Rossmann	115..>150	CDD:304358	21/34 (62%)
		Pyr_redox	294..368	CDD:278498	44/76 (58%)
		Pyr_redox_dim	468..577	CDD:280934	59/108 (55%)
Txnrd1	NP_001035988.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..121		11/64 (17%)
		TGR	125..613	CDD:273624	269/488 (55%)
		Pyr_redox	306..382	CDD:278498	43/75 (57%)
		Pyr_redox_dim	485..595	CDD:280934	60/109 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5178
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S1111
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.680