DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trxr-1 and txnrd3

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_898895.2	Gene:	txnrd3 / 352924	ZFINID:	ZDB-GENE-030327-3	Length:	602	Species:	Danio rerio

Alignment Length:	499	Identity:	260/499 - (52%)
Similarity:	335/499 - (67%)	Gaps:	8/499 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VRKMSTKGGS-YDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVG 166
            ::|:..:|.. ||||||||||||.||||:|||...|.:|..||:|.|||. ||.||:||||||||
Zfish   103 LQKLLGEGSEVYDYDLIVIGGGSGGLACSKEAATLGKKVMVLDYVVPTPQ-GTAWGLGGTCVNVG 166

  Fly   167 CIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYI 231
            |||||||||.:|||.|:.:|..:||...|::..:|..:..:|.|:|.|:||..||.||||.|.|:
Zfish   167 CIPKKLMHQTALLGTAMEDARKFGWEFAEQVTHNWETMKTAVNNYIGSLNWGYRVSLRDKNVNYV 231

  Fly   232 NGLGSFVDSHTLLAKLKSGERTI-TAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDREPGKT 295
            |....||:.|.:.|..|.|:.|. ||..||:|.|.||||..|||..|:.|||||||||...||||
Zfish   232 NAYAEFVEPHKIKATNKRGKETFYTAAQFVLATGERPRYLGIPGDKEFCITSDDLFSLPYCPGKT 296

  Fly   296 LVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEK 360
            |||||.|:.|||.|||.|||.:.|:|||||:||||||.||:.....||..|:.||||.||..:|:
Zfish   297 LVVGASYVALECGGFLAGLGLDVTIMVRSILLRGFDQDMADRAGEYMETHGVKFLRKFVPTKIEQ 361

  Fly   361 QD---DGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTV--QKDKIPVDSQEA 420
            .:   .|::.|..|:.|:.|..|..|:|||.|:||......:.|..|||.:  :..|:||:.:|.
Zfish   362 LEAGTPGRIKVTAKSTESEEVFEGEYNTVLIAVGRDACTGKIGLDKAGVKINEKNGKVPVNDEEQ 426

  Fly   421 TNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEE 485
            |||.:|||:|||:.||.||||||:.||:|||||||.|:|.:.||.:|.||||||:||...|..||
Zfish   427 TNVPHIYAIGDILEGKWELTPVAIQAGKLLARRLYAGATMKCDYVNVPTTVFTPMEYGSCGHPEE 491

  Fly   486 DAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFA 550
            .|::.:|.:.:||:|..:.|.||.:|.:....||.|.:..:..:.||.|.||:||.||||.|||.
Zfish   492 KAIQMYGQENLEVYHSLFWPLEFTVPGRDNNKCYAKIICNKLDNLRVIGFHYLGPNAGEVTQGFG 556

  Fly   551 AALKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLDPTPASC 594
            ||:|.|:|.:.|.||:|||||.||.||.:.:||.||.|.|.:.|
Zfish   557 AAMKCGITKDQLDNTIGIHPTCAEIFTTMEVTKSSGGDITQSGC 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	258/488 (53%)
		NADB_Rossmann	115..>150	CDD:304358	23/34 (68%)
		Pyr_redox	294..368	CDD:278498	42/76 (55%)
		Pyr_redox_dim	468..577	CDD:280934	52/108 (48%)
txnrd3	NP_898895.2	GRX_GRXh_1_2_like	25..106	CDD:239511	0/2 (0%)
		TGR	114..602	CDD:273624	258/488 (53%)
		NADB_Rossmann	114..>160	CDD:304358	31/46 (67%)
		Pyr_redox	295..371	CDD:278498	42/75 (56%)
		Pyr_redox_dim	474..584	CDD:280934	53/109 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830