DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and Dld

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_955417.1	Gene:	Dld / 298942	RGDID:	735073	Length:	509	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	136/494 - (27%)
Similarity:	225/494 - (45%)	Gaps:	49/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVG 166
            |:|..|.:  ..|.|:.|||.|..|...|.:|...|.:..|   ::...||      ||||:|||
  Rat    31 PLRTYSDQ--PIDADVTVIGSGPGGYVAAIKAAQLGFKTVC---IEKNETL------GGTCLNVG 84

  Fly   167 CIPKKLMHQASLLGEAVH--EAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVE 229
            |||.|.:...|......|  :.|:.|..:.| ::.:..|:::..::.:|::........:..||.
  Rat    85 CIPSKALLNNSHYYHLAHGKDFASRGIEIPE-VRLNLEKMMEQKRSAVKALTGGIAHLFKQNKVV 148

  Fly   230 YINGLGSFVDSHTLLAKLKSGE-RTITAQTFVIAVGGR-PRYPDIPGAVEYGITSDDLFSLDREP 292
            ::||.|.....:.:.|....|. :.|..:..:||.|.. ..:|.|....:..::|....||.:.|
  Rat   149 HVNGFGKITGKNQVTATTADGSTQVIGTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVP 213

  Fly   293 GKTLVVGAGYIGLECAGFLKGLGYEPTVM-----VRSIVLRGFDQQMAELVAASMEERGIPFLRK 352
            .|.:|:|||.||:|.....:.||.:.|.:     |..|   |.|.::::.....::::|..|...
  Rat   214 EKLVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGI---GIDMEISKNFQRILQKQGFKFKLN 275

  Fly   353 TVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQ-KDKIPVD 416
            |......|:.|||:.|..:....|:......|.:|..|||:....:|.|...|:.:. |.:|||:
  Rat   276 TKVTGATKKSDGKIDVSVEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEELGIELDPKGRIPVN 340

  Fly   417 SQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVG 481
            ::..|.:.||:|:||::.| |.|...|...|.:....:.||:. .:||..|.:.::|..|.|.||
  Rat   341 TRFQTKIPNIFAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAV-HIDYNCVPSVIYTHPEVAWVG 403

  Fly   482 LSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHG---------DQRVYGLHY 537
            .|||. :|:.|.:        :|..:|.....|    ..|..|:..|         ..|:.|.|.
  Rat   404 KSEEQ-LKEEGVE--------FKVGKFPFAANS----RAKTNADTDGMVKILGHKSTDRILGAHI 455

  Fly   538 IGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEF 576
            :||.|||::...|.||:.|.:...:......|||.:|.|
  Rat   456 LGPGAGEMVNEAALALEYGASCEDVARVCHAHPTLSEAF 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	133/483 (28%)
		NADB_Rossmann	115..>150	CDD:304358	10/34 (29%)
		Pyr_redox	294..368	CDD:278498	22/78 (28%)
		Pyr_redox_dim	468..577	CDD:280934	33/118 (28%)
Dld	NP_955417.1	lipoamide_DH	43..508	CDD:273568	132/480 (28%)
		NADB_Rossmann	45..222	CDD:304358	49/186 (26%)
		Pyr_redox	215..288	CDD:278498	20/75 (27%)
		Pyr_redox_dim	390..496	CDD:280934	33/118 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820