DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trxr-1 and GSR

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_000628.2	Gene:	GSR / 2936	HGNCID:	4623	Length:	522	Species:	Homo sapiens

Alignment Length:	490	Identity:	178/490 - (36%)
Similarity:	261/490 - (53%)	Gaps:	30/490 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 QPVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNV 165
            ||.......|....||.:||||||.|||.|:.|...|||.|.::..|          :|||||||
Human    51 QPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK----------LGGTCVNV 105

  Fly   166 GCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEY 230
            ||:|||:|...::..|.:|:.|.||:...|. |.:|..:.:....::..:|.:.:.:|....:|.
Human   106 GCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEI 169

  Fly   231 INGLGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYP---DIPGAVEYGITSDDLFSLDREP 292
            |.|..:|........:: ||:: .||...:||.||.|..|   .|||| ..|||||..|.|:..|
Human   170 IRGHAAFTSDPKPTIEV-SGKK-YTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELP 231

  Fly   293 GKTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEERGIPFLRKTVPL 356
            |::::||||||.:|.||.|..||.:.::|:| ..|||.||..::......:|..|:..|:.:...
Human   232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVK 296

  Fly   357 SVEKQDDGKLLVKYKNVETGE-----EAEDVYDTVLWAIGRKGLVDDLNLPNAGV-TVQKDKIPV 415
            .|:|...| |.|.......|.     ...|| |.:||||||.....||:|...|: |..|..|.|
Human   297 EVKKTLSG-LEVSMVTAVPGRLPVMTMIPDV-DCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV 359

  Fly   416 DSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYG-GSTQRMDYKDVATTVFTPLEYAC 479
            |..:.|||..||||||:. ||..|||||:.|||.||.||:. ....::||.::.|.||:......
Human   360 DEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGT 423

  Fly   480 VGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGE 544
            |||:|::|:.::|.:.::.:...:.|....:.::..: |.:|.|. .:.:::|.|:|..|....|
Human   424 VGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CVMKMVC-ANKEEKVVGIHMQGLGCDE 486

  Fly   545 VIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 579
            ::||||.|:|.|.|.....|||.||||::||...|
Human   487 MLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	175/478 (37%)
		NADB_Rossmann	115..>150	CDD:304358	18/34 (53%)
		Pyr_redox	294..368	CDD:278498	26/74 (35%)
		Pyr_redox_dim	468..577	CDD:280934	35/108 (32%)
GSR	NP_000628.2	gluta_reduc_1	63..522	CDD:273614	175/478 (37%)
		Pyr_redox	233..307	CDD:278498	26/74 (35%)
		Pyr_redox_dim	412..520	CDD:280934	35/109 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850