DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and Txnrd2

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_038739.2	Gene:	Txnrd2 / 26462	MGIID:	1347023	Length:	527	Species:	Mus musculus

Alignment Length:	492	Identity:	270/492 - (54%)
Similarity:	347/492 - (70%)	Gaps:	5/492 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 STKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 171
            |..||...:||:||||||.||||||||...|.:||..|:|:|:|. |||||:|||||||||||||
Mouse    35 SAAGGQQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPR-GTKWGLGGTCVNVGCIPKK 98

  Fly   172 LMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGS 236
            |||||:|||..:.:|..|||.|.:.::.:|..:.::||||:||:||..||.|:|:||:|.|...|
Mouse    99 LMHQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKAS 163

  Fly   237 FVDSHTLLAKLKSGERT-ITAQTFVIAVGGRPRYP-DIPGAVEYGITSDDLFSLDREPGKTLVVG 299
            |||.||:....|.|:.| ::|:..|||.||||||| .:.||:||||||||:|.|...||||||||
Mouse   164 FVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESPGKTLVVG 228

  Fly   300 AGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVEKQDDG 364
            |.|:.|||||||.|:|.:.|||:|||.||||||||:.||...||..|..||:..||..::|....
Mouse   229 ASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHGTQFLKGCVPSHIKKLPTN 293

  Fly   365 KLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTV--QKDKIPVDSQEATNVANIY 427
            :|.|.:::..:|:|....:|||||||||......|||..||::.  :..||.||:||||:|.:||
Mouse   294 QLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPKNQKIIVDAQEATSVPHIY 358

  Fly   428 AVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFG 492
            |:||:..|:|||||.|:.||:|||:||:|.|:..|||.:|.|||||||||.|||||||:||...|
Mouse   359 AIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHG 423

  Fly   493 ADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGL 557
            .:.:||:|.||||.||.:..:....||:|.|..|...|.|.|||::||.||||.||||..:|.|.
Mouse   424 QEHVEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGA 488

  Fly   558 TINTLINTVGIHPTTAEEFTRLAITKRSGLDPTPASC 594
            :...::.|||||||.:||..:|.|:|||||:||...|
Mouse   489 SYAQVMQTVGIHPTCSEEVVKLHISKRSGLEPTVTGC 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	267/486 (55%)
		NADB_Rossmann	115..>150	CDD:304358	22/34 (65%)
		Pyr_redox	294..368	CDD:278498	42/73 (58%)
		Pyr_redox_dim	468..577	CDD:280934	59/108 (55%)
Txnrd2	NP_038739.2	TGR	43..527	CDD:273624	267/484 (55%)
		NADB_Rossmann	43..>70	CDD:304358	18/26 (69%)
		Pyr_redox	223..289	CDD:278498	40/65 (62%)
		Pyr_redox_dim	399..508	CDD:280934	59/108 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I909
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4701
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1165
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm42464
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	1	1.100	-	-	LDO	PTHR48105
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840