DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and pgr1

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_595589.1	Gene:	pgr1 / 2540156	PomBaseID:	SPBC17A3.07	Length:	464	Species:	Schizosaccharomyces pombe

Alignment Length:	488	Identity:	170/488 - (34%)
Similarity:	260/488 - (53%)	Gaps:	37/488 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVG 166
            |:.|:        :|.:||||||.|||.|:.|..:||:||.::         ....:||||||.|
pombe     3 PISKV--------FDYLVIGGGSGGLASARRAAKHGAKVALIE---------ASGRLGGTCVNYG 50

  Fly   167 CIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYI 231
            |:|||:|...:.|...:..|...|:...:....||..:.:....:|..:|.:...::....|.||
pombe    51 CVPKKIMWNIADLVAKMKTAKQNGFPNSQLGSFDWGMIKRKRDAYIGRLNGIYERNVNKDGVAYI 115

  Fly   232 NGLGSFVDSHTLLAKLK--SGERTITAQTFVIAVGGRPRYPD-IPGAVEYGITSDDLFSLDREPG 293
            :|..|||....:...:.  ||.:..:|:..:|||||.|.:|. |||| ||||.||..|.|:.:|.
pombe   116 SGHASFVSPTEVAVDMNDGSGTQVFSAKYILIAVGGHPIWPSHIPGA-EYGIDSDGFFELESQPK 179

  Fly   294 KTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEERGIPFLRKTVPL- 356
            :..:||||||.:|.||....||.|..:.:| |..||.||..:::.:....:..||.....::..
pombe   180 RVAIVGAGYIAVELAGVFAALGTETHMFIRQSKFLRKFDPIISDGIMDHFQHIGINVHTNSLEFK 244

  Fly   357 SVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGV-TVQKDKIPVDSQEA 420
            .|||...|:|.:..::..|..     .||:||||||...:..|.|..||| |:....|..|:.:.
pombe   245 KVEKLPSGELCIHQQDGSTFN-----VDTLLWAIGRAPKIQGLRLEKAGVKTLPNGIIIADTYQR 304

  Fly   421 TNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGG-STQRMDYKDVATTVFTPLEYACVGLSE 484
            |||..:.::||:. ||.||||||:.|||.|:.||:|| ....:||::|.:.||...|...:||:|
pombe   305 TNVPTVLSLGDVC-GKLELTPVAIAAGRRLSDRLFGGIKDAHLDYEEVPSVVFAHPEAGTIGLTE 368

  Fly   485 EDAVKQFGADEIEVFHGYYKPTEFFIPQK--SVRYCYLKAVAERHGD-QRVYGLHYIGPVAGEVI 546
            ::|:.::|..:|:|::..:....:.:.::  .|...|....|   |. |:|.|||.:|..:.|::
pombe   369 QEAIDKYGESQIKVYNTKFNGLNYSMVEQEDKVPTTYKLVCA---GPLQKVVGLHLVGDFSAEIL 430

  Fly   547 QGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 579
            |||..|:|.|.|.:...:.|.||||:|||...|
pombe   431 QGFGVAIKMGATKSDFDSCVAIHPTSAEELVTL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	168/477 (35%)
		NADB_Rossmann	115..>150	CDD:304358	16/34 (47%)
		Pyr_redox	294..368	CDD:278498	25/75 (33%)
		Pyr_redox_dim	468..577	CDD:280934	36/111 (32%)
pgr1	NP_595589.1	PRK06116	5..463	CDD:235701	168/484 (35%)
		NADB_Rossmann	20..209	CDD:304358	69/198 (35%)
		Pyr_redox	180..256	CDD:278498	25/75 (33%)
		Pyr_redox_dim	352..462	CDD:280934	36/112 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I846
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I769
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm47011
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
TreeFam	0	0.000	Not matched by this tool.
	8	7.890