DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and Txnrd3

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001171529.1	Gene:	Txnrd3 / 232223	MGIID:	2386711	Length:	652	Species:	Mus musculus

Alignment Length:	510	Identity:	270/510 - (52%)
Similarity:	346/510 - (67%)	Gaps:	9/510 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 CDRAAMYAQP--VRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTK 155
            |||.....|.  ::|:.....::|||||:|||||.||:|||||...|.:|..||||.|:|. ||.
Mouse   142 CDRTFQAHQNGLLQKLLQDDSAHDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQ-GTT 205

  Fly   156 WGVGGTCVNVGCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTR 220
            ||:||||||||||||||||||:|||.|:.:|..|||..::::|.:|..:.:::|:||.|:||..|
Mouse   206 WGLGGTCVNVGCIPKKLMHQAALLGHALQDAKKYGWEYNQQVKHNWEAMTEAIQSHIGSLNWGYR 270

  Fly   221 VDLRDKKVEYINGLGSFVDSHTLLAKLKSGERTI-TAQTFVIAVGGRPRYPDIPGAVEYGITSDD 284
            |.||:|.|.|:|..|.|||.|.:.|..|.|:.|. ||..||||.|.||||..|.|..||.|||||
Mouse   271 VTLREKGVTYVNSFGEFVDLHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDD 335

  Fly   285 LFSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPF 349
            ||||...||.||||||.|:||||||||.|||.:.||||||::||||||:|||.|.:.:|::|:.|
Mouse   336 LFSLPYCPGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLEQQGVKF 400

  Fly   350 LRKTVPLSV---EKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTV--Q 409
            .||..|:.|   ||...|||.|..|:.|..|..|.:|:|||.||||......:.|...||.:  :
Mouse   401 QRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGVKINEK 465

  Fly   410 KDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTP 474
            ..||||:..|.|||.::||:|||:.|||||||||:.||:||||||:|.|.::.||.::.||||||
Mouse   466 NGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDYINIPTTVFTP 530

  Fly   475 LEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIG 539
            |||.|.|||||.|::.:..:.:||:|..:.|.|:.:..:....||.|.:..:..::||.|.|.:|
Mouse   531 LEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDNNTCYAKIICNKFDNERVVGFHLLG 595

  Fly   540 PVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLDPTPASC 594
            |.|||:.||||||:|.|||...|.:|:|||||..|.||.|.|||.||||.|...|
Mouse   596 PNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGC 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	265/488 (54%)
		NADB_Rossmann	115..>150	CDD:304358	23/34 (68%)
		Pyr_redox	294..368	CDD:278498	46/76 (61%)
		Pyr_redox_dim	468..577	CDD:280934	51/108 (47%)
Txnrd3	NP_001171529.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		GRX_GRXh_1_2_like	76..157	CDD:239511	4/14 (29%)
		TGR	164..652	CDD:273624	265/488 (54%)
		Pyr_redox	347..421	CDD:278498	44/73 (60%)
		Pyr_redox_dim	524..634	CDD:280934	52/109 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5178
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720