DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and trxr-2

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_498971.1	Gene:	trxr-2 / 176259	WormBaseID:	WBGene00014028	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	237/502 - (47%)
Similarity:	321/502 - (63%)	Gaps:	18/502 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVG 166
            |:|::.:   |..:||||||.||.||:|:|.|...||.||.:|.|:|||. |..||:||||.|||
Worm    11 PIRRLFS---SNKFDLIVIGAGSGGLSCSKRAADLGANVALIDAVEPTPH-GHSWGIGGTCANVG 71

  Fly   167 CIPKKLMHQASLLGEAVHEAAAYGWN-VD-EKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVE 229
            ||||||||||:::|:.:..|..|||| :| ||||.||:.|.::|.:.:|:.||:.||.|..||:.
Worm    72 CIPKKLMHQAAIVGKELKHADKYGWNGIDQEKIKHDWNVLSKNVNDRVKANNWIYRVQLNQKKIN 136

  Fly   230 YINGLGSFVDSHTLLAKLKSGERT---ITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDRE 291
            |.|....|||...::.......:|   ::|...||:.|.||:||:|||| |.||||||||:|...
Worm   137 YFNAYAEFVDKDKIVITGTDKNKTKNFLSAPNVVISTGLRPKYPNIPGA-ELGITSDDLFTLASV 200

  Fly   292 PGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPL 356
            |||||:||.||:.|||||||........|:||||.|:|||:.....|...::..|:     .|..
Worm   201 PGKTLIVGGGYVALECAGFLSAFNQNVEVLVRSIPLKGFDRDCVHFVMEHLKTTGV-----KVKE 260

  Fly   357 SVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQK--DKIPVDSQE 419
            .||.:....:..|.|...||....:.||||:||.||...:..|||.||||...|  .||..|..:
Worm   261 HVEVERVEAVGSKKKVTFTGNGGVEEYDTVIWAAGRVPNLKSLNLDNAGVRTDKRSGKILADEFD 325

  Fly   420 ATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSE 484
            ..:...:||||||:..:.||||:|:.:|:|||.||:..|.|.:.:..||||||||||.:.|||:|
Worm   326 RASCNGVYAVGDIVQDRQELTPLAIQSGKLLADRLFSNSKQIVRFDGVATTVFTPLELSTVGLTE 390

  Fly   485 EDAVKQFGADEIEVFHGYYKPTEFFIPQ-KSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQG 548
            |:|:::.|.|.|||||.::.|.|:.:|| |...:||:|||..|...|::.|||::||.|.|||||
Worm   391 EEAIQKHGEDSIEVFHSHFTPFEYVVPQNKDSGFCYVKAVCTRDESQKILGLHFVGPNAAEVIQG 455

  Fly   549 FAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLDPTPASCC 595
            :|.|.:.|::::.|.||:.|||.::|||.:|.||||||.||....||
Worm   456 YAVAFRVGISMSDLQNTIAIHPCSSEEFVKLHITKRSGQDPRTQGCC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	232/489 (47%)
		NADB_Rossmann	115..>150	CDD:304358	20/34 (59%)
		Pyr_redox	294..368	CDD:278498	28/73 (38%)
		Pyr_redox_dim	468..577	CDD:280934	56/109 (51%)
trxr-2	NP_498971.1	TGR	19..503	CDD:273624	234/491 (48%)
		NADB_Rossmann	20..>49	CDD:304358	17/28 (61%)
		Pyr_redox	203..279	CDD:278498	30/80 (38%)
		Pyr_redox_dim	374..484	CDD:280934	56/109 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I3301
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4701
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm14419
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	1	1.100	-	-	LDO	PTHR48105
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.860