DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and gsr-1

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001021220.1	Gene:	gsr-1 / 175467	WormBaseID:	WBGene00008117	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	494	Identity:	189/494 - (38%)
Similarity:	276/494 - (55%)	Gaps:	45/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 STKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKK 171
            |...|..::|.:||||||.|:|.|:.|...|..|..::..:          :|||||||||:|||
Worm    13 SIMSGVKEFDYLVIGGGSGGIASARRAREFGVSVGLIESGR----------LGGTCVNVGCVPKK 67

  Fly   172 LMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGS 236
            :|:..||..|.:.:.|.||::|... |.||..:.:|...:||.:|.:....|:...||||.|..:
Worm    68 VMYNCSLHAEFIRDHADYGFDVTLN-KFDWKVIKKSRDEYIKRLNGLYESGLKGSSVEYIRGRAT 131

  Fly   237 FVDSHTLL---AKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDREPGKTLVV 298
            |.:..|:.   ||.: |:.|:      |||||:|..|:|.|| |:||.||..|.|:..|.:|:||
Worm   132 FAEDGTVEVNGAKYR-GKNTL------IAVGGKPTIPNIKGA-EHGIDSDGFFDLEDLPSRTVVV 188

  Fly   299 GAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEERGIPF-LRKTVPLS-VEK 360
            |||||.:|.||.|..||.:..:::| ..|||.||:.:::.:.|.|:|...|. |.|...:: |.|
Worm   189 GAGYIAVEIAGVLANLGSDTHLLIRYDKVLRTFDKMLSDELTADMDEETNPLHLHKNTQVTEVIK 253

  Fly   361 QDDGKLLVKYKNVETG--EEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQKD-KIPVDSQEATN 422
            .|||.|.:|   ..||  |:.:    |::|||||..|..:|||...||...|. .|.||..:.|:
Worm   254 GDDGLLTIK---TTTGVIEKVQ----TLIWAIGRDPLTKELNLERVGVKTDKSGHIIVDEYQNTS 311

  Fly   423 VANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGST-QRMDYKDVATTVFTPLEYACVGLSEED 486
            ...|.:|||.. ||..|||||:.|||.|:.||:.|.| .::.|:::||.||:......|||:|.:
Worm   312 APGILSVGDDT-GKFLLTPVAIAAGRRLSHRLFNGETDNKLTYENIATVVFSHPLIGTVGLTEAE 375

  Fly   487 AVKQFGADEIEVFHGYYKPTEFFIPQ-KSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFA 550
            ||:::|.||:.::...:.|..|.:.: |......|..|.:   |::|.|:|..|..:.|::||||
Worm   376 AVEKYGKDEVTLYKSRFNPMLFAVTKHKEKAAMKLVCVGK---DEKVVGVHVFGVGSDEMLQGFA 437

  Fly   551 AALKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLDP 589
            .|:..|.|......||.||||:|||.    :|.|.|:.|
Worm   438 VAVTMGATKKQFDQTVAIHPTSAEEL----VTMRGGVKP 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	187/488 (38%)
		NADB_Rossmann	115..>150	CDD:304358	13/34 (38%)
		Pyr_redox	294..368	CDD:278498	32/76 (42%)
		Pyr_redox_dim	468..577	CDD:280934	40/109 (37%)
gsr-1	NP_001021220.1	PRK06116	19..467	CDD:235701	184/481 (38%)
		Pyr_redox	184..261	CDD:278498	32/76 (42%)
		Pyr_redox_dim	357..465	CDD:280934	40/114 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950