Protein Alignment Trxr1 and DLD

DIOPT Version :10

• Sequence 1: NP_727251.1
• Gene: Trxr1 / 31760
• FlyBaseID: FBgn0020653
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_000099.2
• Gene: DLD / 1738
• HGNCID: 2898
• Length: 509
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 138/496 - (27%)
• Similarity: 225/496 - (45%)
• Gaps: 49/496 - (9%)

  Fly   100 AQPVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVN 164
            |.|:|..:.:  ..|.|:.|||.|..|...|.:|...|.:..|   ::...||      ||||:|
Human    29 AVPLRTYADQ--PIDADVTVIGSGPGGYVAAIKAAQLGFKTVC---IEKNETL------GGTCLN 82

  Fly   165 VGCIPKKLMHQASLLGEAVH--EAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKK 227
            |||||.|.:...|......|  :.|:.|..:.| ::.:..|:::.....:|::........:..|
Human    83 VGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNK 146

  Fly   228 VEYINGLGSFVDSHTLLA-KLKSGERTITAQTFVIAVGGR-PRYPDIPGAVEYGITSDDLFSLDR 290
            |.::||.|.....:.:.| |...|.:.|..:..:||.|.. ..:|.|....:..::|....||.:
Human   147 VVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKK 211

  Fly   291 EPGKTLVVGAGYIGLECAGFLKGLGYEPTVM-----VRSIVLRGFDQQMAELVAASMEERGIPFL 350
            .|.|.:|:|||.||:|.....:.||.:.|.:     |..:   |.|.::::.....::::|..|.
Human   212 VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV---GIDMEISKNFQRILQKQGFKFK 273

  Fly   351 RKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQ-KDKIP 414
            ..|......|:.|||:.|..:....|:......|.:|..|||:....:|.|...|:.:. :.:||
Human   274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIP 338

  Fly   415 VDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYAC 479
            |:::..|.:.||||:||::.| |.|...|...|.:....:.||:. .:||..|.:.::|..|.|.
Human   339 VNTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAV-HIDYNCVPSVIYTHPEVAW 401

  Fly   480 VGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHG---------DQRVYGL 535
            ||.|||. :|:.|.:        ||..:|.....|    ..|..|:..|         ..||.|.
Human   402 VGKSEEQ-LKEEGIE--------YKVGKFPFAANS----RAKTNADTDGMVKILGQKSTDRVLGA 453

  Fly   536 HYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEF 576
            |.:||.|||::...|.||:.|.:...:......|||.:|.|
Human   454 HILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAF 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trxr1	NP_727251.1	DAO	59..>160	CDD:477422	16/59 (27%)
		TGR	113..595	CDD:273624	135/483 (28%)
DLD	NP_000099.2	Lpd	40..501	CDD:440861	135/483 (28%)