DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trxr-1 and Gsr

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_034474.4	Gene:	Gsr / 14782	MGIID:	95804	Length:	500	Species:	Mus musculus

Alignment Length:	513	Identity:	182/513 - (35%)
Similarity:	265/513 - (51%)	Gaps:	28/513 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PAGSGAGAPPPFQHPHCDRAAMYAQPVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVA 141
            |...|.||.|..:..........|.|.........:..:|.:||||||.|||.|:.|...|||.|
Mouse     5 PRALGVGAAPSLRRAARALTCAMASPGEPQPPAPDTSSFDYLVIGGGSGGLASARRAAELGARAA 69

  Fly   142 CLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQ 206
            .::..|          :|||||||||:|||:|...::..|.:|:...||:...|. |..||.:.|
Mouse    70 VVESHK----------LGGTCVNVGCVPKKVMWNTAVHSEFMHDHVDYGFQSCEG-KFSWHVIKQ 123

  Fly   207 SVQNHIKSVNWVTRVDLRDKKVEYINGLGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYP- 270
            ....::..:|.:.:.:|....:|.|:|..:|.|......::..  :..||...:||.||.|..|
Mouse   124 KRDAYVSRLNTIYQNNLTKSHIEIIHGYATFADGPRPTVEVNG--KKFTAPHILIATGGVPTVPH 186

  Fly   271 --DIPGAVEYGITSDDLFSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQ 332
              .|||| ..|||||..|.|:..|.::::||||||.:|.||.|..||.:.::|:| ..|||.||.
Mouse   187 ESQIPGA-SLGITSDGFFQLEDLPSRSVIVGAGYIAVEIAGILSALGSKTSLMIRHDKVLRNFDS 250

  Fly   333 QMAELVAASMEERGIPFLRKTVPLSVEKQDDGKLLVKYKNV----ETGEEAEDVYDTVLWAIGRK 393
            .::......:|..|:..|:.|....|:|...|..|....:|    .|.....|| |.:||||||.
Mouse   251 LISSNCTEELENAGVEVLKFTQVKEVKKTSSGLELQVVTSVPGRKPTTTMIPDV-DCLLWAIGRD 314

  Fly   394 GLVDDLNLPNAGV-TVQKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYG- 456
            .....|||...|: |.:|..|.||..:.|||..:|||||:. ||..|||||:.|||.||.||:.
Mouse   315 PNSKGLNLNKVGIQTDEKGHILVDEFQNTNVKGVYAVGDVC-GKALLTPVAIAAGRKLAHRLFEC 378

  Fly   457 GSTQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLK 521
            ....::||.::.|.||:......|||:|::||.::|.|.::::...:.|....:..:..: |.:|
Mouse   379 KQDSKLDYDNIPTVVFSHPPIGTVGLTEDEAVHKYGKDNVKIYSTAFTPMYHAVTTRKTK-CVMK 442

  Fly   522 AVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 579
            .|. .:.:::|.|:|..|....|::||||.|:|.|.|.....|||.||||::||...|
Mouse   443 MVC-ANKEEKVVGIHMQGIGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	175/477 (37%)
		NADB_Rossmann	115..>150	CDD:304358	17/34 (50%)
		Pyr_redox	294..368	CDD:278498	26/74 (35%)
		Pyr_redox_dim	468..577	CDD:280934	37/108 (34%)
Gsr	NP_034474.4	gluta_reduc_1	42..500	CDD:273614	175/476 (37%)
		Pyr_redox	211..287	CDD:278498	27/75 (36%)
		Pyr_redox_dim	390..498	CDD:280934	37/109 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850