Protein Alignment Trxr1 and TXNRD2

DIOPT Version :10

• Sequence 1: NP_727251.1
• Gene: Trxr1 / 31760
• FlyBaseID: FBgn0020653
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_006431.2
• Gene: TXNRD2 / 10587
• HGNCID: 18155
• Length: 524
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 279/526 - (53%)
• Similarity: 353/526 - (67%)
• Gaps: 31/526 - (5%)

  Fly    73 GGNAPAGSGAGAPPPFQHPHCDRAAMYAQPVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNG 137
            ||...|..||.|                          |..||||:|:||||.||||||||...|
Human    24 GGVRGAARGAAA--------------------------GQRDYDLLVVGGGSGGLACAKEAAQLG 62

  Fly   138 ARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWH 202
            .:||.:|:|:|:|. ||:||:||||||||||||||||||:|||..:.:|..|||.|.:.:..||.
Human    63 RKVAVVDYVEPSPQ-GTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWR 126

  Fly   203 KLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGSFVDSHTLLAKLKSG-ERTITAQTFVIAVGGR 266
            |:.::||||:||:||..||.|:|:||:|.|...||||.||:....|.| |..::|...:||.|||
Human   127 KMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGR 191

  Fly   267 PRYP-DIPGAVEYGITSDDLFSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGF 330
            |||| .|.||:||||||||:|.|...|||||||||.|:.|||||||.|:|.:.|:|:|||.||||
Human   192 PRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGF 256

  Fly   331 DQQMAELVAASMEERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGL 395
            ||||:.:|...|...|..|||...|..|.:..||:|.|.:::..||:|....:|||||||||...
Human   257 DQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPD 321

  Fly   396 VDDLNLPNAGVTVQKD--KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGS 458
            ...|||..|||....|  ||.|||:|||:|.:|||:||::.|:|||||:|::|||||.:||:|||
Human   322 TRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGS 386

  Fly   459 TQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAV 523
            :..|||.:|.|||||||||.|||||||:||.:.|.:.:||:|.:|||.||.:..:....||:|.|
Human   387 SDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMV 451

  Fly   524 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLD 588
            ..|...|.|.|||::||.||||.||||..:|.|.:...::.|||||||.:||..:|.|:||||||
Human   452 CLREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLD 516

  Fly   589 PTPASC 594
            ||...|
Human   517 PTVTGC 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trxr1	NP_727251.1	DAO	59..>160	CDD:477422	35/86 (41%)
		TGR	113..595	CDD:273624	272/486 (56%)
TXNRD2	NP_006431.2	TGR	39..524	CDD:273624	272/485 (56%)