DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-1 and dld

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	XP_002933161.3	Gene:	dld / 100485480	XenbaseID:	XB-GENE-982851	Length:	509	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	137/489 - (28%)
Similarity:	223/489 - (45%)	Gaps:	43/489 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCI 168
            |..|.|  :.:.|:.|:|.|..|...|.:|...|.:..|   |:...||      ||||:|||||
Frog    33 RNYSEK--ALEADVTVVGSGPGGYVAAIKAAQLGFQTVC---VEKNDTL------GGTCLNVGCI 86

  Fly   169 PKKLMHQASLLGEAVH--EAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYI 231
            |.|.:...|.|....|  :.|:.|..| ..|:.:..|:::.....:||:........:..||.::
Frog    87 PSKALLNNSHLYHLAHGKDFASRGIEV-TGIRLNLEKMMEQKSGAVKSLTTGIAHLFKQNKVVHV 150

  Fly   232 NGLGSFVDSHTLLA-KLKSGERTITAQTFVIAVGGR-PRYPDIPGAVEYGITSDDLFSLDREPGK 294
            .|.|.....:.:.| |.....:.|..:..:||.|.. ..:..||...|..::|....||.:.|.|
Frog   151 QGFGRITGKNQVTATKADGSTQVINTKNILIATGSEVAPFSGIPIDEETIVSSTGALSLKQVPEK 215

  Fly   295 TLVVGAGYIGLECAGFLKGLGYEPTVM--VRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLS 357
            .:|:|||.||:|.....:.||.:.|.:  :..:...|.|.::::.....::::|:.|...|....
Frog   216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGLGIDMEISKNFQRILQKQGLKFKLNTKVTG 280

  Fly   358 VEKQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTV-QKDKIPVDSQEAT 421
            ..|:.|||:.|..:....|:|.....|.:|..|||:...::|.|...|:.: .:.:||::|:..|
Frog   281 ATKRPDGKIDVSIEAAAGGKEEVITCDVLLVCIGRRPYTENLGLQELGIELDNRGRIPINSRFQT 345

  Fly   422 NVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEED 486
            .:.||||:||::.| |.|...|...|.:....:.||:. .:||..|.:.::|..|.|.||.|||.
Frog   346 KMPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAV-HIDYNCVPSVIYTHPEVAWVGKSEEQ 408

  Fly   487 AVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHG---------DQRVYGLHYIGPVA 542
             :|:.|.:        ||..:|.....|    ..|..|:..|         ..|:.|.|.:|..|
Frog   409 -LKEEGTE--------YKVGKFPFAANS----RAKTNADTDGLVKILSHKSTDRMLGAHILGAGA 460

  Fly   543 GEVIQGFAAALKSGLTINTLINTVGIHPTTAEEF 576
            ||:|...|.|::.|.:...:......|||.:|.|
Frog   461 GEMINEAALAMEYGASCEDVARVCHAHPTVSEAF 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	134/480 (28%)
		NADB_Rossmann	115..>150	CDD:304358	10/34 (29%)
		Pyr_redox	294..368	CDD:278498	20/75 (27%)
		Pyr_redox_dim	468..577	CDD:280934	33/118 (28%)
dld	XP_002933161.3	lipoamide_DH	43..508	CDD:273568	134/477 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010