DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Trxr-1 and gsr

DIOPT Version :9

Sequence 1:NP_727251.1 Gene:Trxr-1 / 31760 FlyBaseID:FBgn0020653 Length:596 Species:Drosophila melanogaster
Sequence 2:NP_001120626.2 Gene:gsr / 100145793 XenbaseID:XB-GENE-997099 Length:590 Species:Xenopus tropicalis


Alignment Length:514 Identity:176/514 - (34%)
Similarity:271/514 - (52%) Gaps:44/514 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 FQHPHCDRAAMY------AQPVRKMSTKGGSYD--YDLIVIGGGSAGLACAKEAVLNGARVACLD 144
            |..|||....:|      .:||....:..|...  :|.:|:||||.|||.|:.|...|||.|.::
 Frog    98 FFSPHCPLPRVYHTSPAMHKPVPDSHSSDGHLPRYFDYLVVGGGSGGLASARRAAELGARTAVVE 162

  Fly   145 FVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQ 209
            ..|          :|||||||||:|||:|..|::..|.:|:...||:.. ..||..|..:.:...
 Frog   163 SSK----------LGGTCVNVGCVPKKIMWNAAIHSEYIHDHEDYGFET-SAIKFTWKVIKEKRD 216

  Fly   210 NHIKSVNWVTRVDLRDKKVEYINGLGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYP---D 271
            .::..:|.:.:.:|:..::|.|.|..:|........:: :|::.| |...:||.||:|..|   :
 Frog   217 AYVSRLNDIYQNNLQKAQIEIIRGQANFTSDSEPTVEV-NGQKYI-APHILIATGGKPSMPSDAE 279

  Fly   272 IPGAVEYGITSDDLFSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMA 335
            :||| ..|||||..|.|...|.:::|||||||.:|..|.|..||.:.::::| ..|||.||..::
 Frog   280 VPGA-SLGITSDGFFQLTDLPRRSVVVGAGYIAIEIVGILSALGSKASLLIRQDKVLRTFDSMIS 343

  Fly   336 ELVAASMEERGIPFLRKTVPLSVEKQDDGKLLVKYKNVE--------TGEEAEDVYDTVLWAIGR 392
            ......:|..|:...:.....||:|...|..:    ||:        |....:|| |.:||||||
 Frog   344 SNCTEELENAGVEVWKYAQVKSVKKSATGLEI----NVQCSMPGRKPTVRTIQDV-DCLLWAIGR 403

  Fly   393 KGLVDDLNLPNAGVTV-QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLY- 455
            ....:||.|.|.|:.: :|..|.||..:.|:...:|||||:. |:..|||||:.|||.|:.||: 
 Frog   404 DPNTEDLGLENLGLELDEKGHIVVDEFQNTSRKGVYAVGDVC-GRALLTPVAIAAGRKLSHRLFE 467

  Fly   456 GGSTQRMDYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYL 520
            |....::||.::.|.||:......|||:||:||...|.:.::|:...:.|....:.::..: |.:
 Frog   468 GQEDSKLDYDNIPTVVFSHPPIGTVGLTEEEAVTAKGRENVKVYTTSFSPMYHAVTRRKTK-CVM 531

  Fly   521 KAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 579
            |.|.... :::|.|||..|....|::|||:.|:|.|.|.....|||.||||::||...|
 Frog   532 KLVCVGK-EEKVVGLHMQGLGCDEMLQGFSVAIKMGATKKDFDNTVAIHPTSSEELVTL 589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Trxr-1NP_727251.1 TGR 113..595 CDD:273624 168/483 (35%)
NADB_Rossmann 115..>150 CDD:304358 16/34 (47%)
Pyr_redox 294..368 CDD:278498 24/74 (32%)
Pyr_redox_dim 468..577 CDD:280934 38/108 (35%)
gsrNP_001120626.2 Pyr_redox_2 131..590 CDD:393463 168/481 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D164705at33208
OrthoFinder 1 1.000 - - FOG0000578
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1089
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.010

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