DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trxr-1 and txnrd2

DIOPT Version :9

Sequence 1:	NP_727251.1	Gene:	Trxr-1 / 31760	FlyBaseID:	FBgn0020653	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001120487.2	Gene:	txnrd2 / 100145605	XenbaseID:	XB-GENE-5767949	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	288/497 - (57%)
Similarity:	361/497 - (72%)	Gaps:	6/497 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 VRKMSTKGG-SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVG 166
            :||....|| .:||||:||||||.||||||:|...|.:||..|:|:|:|. |||||:||||||||
Frog     7 LRKAGLLGGIRHDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPR-GTKWGIGGTCVNVG 70

  Fly   167 CIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYI 231
            ||||||||||:|:|..:.:|..|||:...:|:.:|.|:.::|||::||:||..|:.|:||||:|.
Frog    71 CIPKKLMHQAALIGSTLKDAPHYGWDTPNEIQHNWGKMAKAVQNYVKSLNWGHRIQLQDKKVKYF 135

  Fly   232 NGLGSFVDSHTLLAKLKSGERT-ITAQTFVIAVGGRPRYP-DIPGAVEYGITSDDLFSLDREPGK 294
            |...||||.|.:....|:|:.| :||:..|||.||||:|| .:|||:||||||||||.|...|||
Frog   136 NMKASFVDEHCIRGVTKAGKETLVTAENIVIATGGRPKYPTHVPGALEYGITSDDLFWLKESPGK 200

  Fly   295 TLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKTVPLSVE 359
            ||||||.|:.|||||||.|:|.:...|||||.|||||||||.||...||..|..||.|..|.:||
Frog   201 TLVVGASYVSLECAGFLTGIGLDTAAMVRSIPLRGFDQQMAYLVTDYMELHGTKFLWKCTPSNVE 265

  Fly   360 KQDDGKLLVKYKNVETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQKD--KIPVDSQEATN 422
            |..:|||.|.:||.|:|:|..|:||||:||:||......|||...||.|:.|  ||.|::.|||:
Frog   266 KLKNGKLEVTWKNTESGKEGADIYDTVMWAVGRAAETQYLNLEKVGVDVKSDTGKIIVNASEATS 330

  Fly   423 VANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKDVATTVFTPLEYACVGLSEEDA 487
            |.:|||:|||..|:|||||.|:.||:|||.||:.||.:.|||..|.|||||||||.|||:|||||
Frog   331 VPHIYAIGDITEGRPELTPTAIAAGKLLASRLFSGSAELMDYDSVPTTVFTPLEYGCVGISEEDA 395

  Fly   488 VKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAA 552
            .:::|.|.|||||.:|||.||.:.:::...||:|.:..|..|||:.|||:.||.|||||||||..
Frog   396 KERYGDDNIEVFHAFYKPLEFIVAERNGSQCYIKIICLRTQDQRILGLHFTGPNAGEVIQGFALG 460

  Fly   553 LKSGLTINTLINTVGIHPTTAEEFTRLAITKRSGLDPTPASC 594
            :|.|.|.:.|:.|||||||.|||.|:|.||||||||||...|
Frog   461 IKCGATYHQLMRTVGIHPTCAEEVTKLHITKRSGLDPTVTGC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-1	NP_727251.1	TGR	113..595	CDD:273624	284/486 (58%)
		NADB_Rossmann	115..>150	CDD:304358	22/34 (65%)
		Pyr_redox	294..368	CDD:278498	46/73 (63%)
		Pyr_redox_dim	468..577	CDD:280934	64/108 (59%)
txnrd2	NP_001120487.2	Pyr_redox_dim	18..504	CDD:332164	284/486 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4701
Inparanoid	1	1.050	579	1.000	Inparanoid score	I1018
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm47567
Panther	1	1.100	-	-	LDO	PTHR48105
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190