Protein Alignment ONECUT1 and onecut

DIOPT Version :10

• Sequence 1: NP_004489.1
• Gene: ONECUT1 / 3175
• HGNCID: 8138
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_524842.2
• Gene: onecut / 45816
• FlyBaseID: FBgn0028996
• Length: 1081
• Species: Drosophila melanogaster
• Alignment Length: 779
• Identity: 221/779 - (28%)
• Similarity: 284/779 - (36%)
• Gaps: 368/779 - (47%)

Human    17 SHEPVPAPADLLGGSPHARSSVAHRGSHLPPAHPRSMGM-----------ASLLDGGSGGGDYHH 70
            ||.|...|...:....|.||:.:..|  |...|...:.:           ....|.|...||..:
  Fly   234 SHHPHLQPHTQIIHGLHQRSTHSEMG--LDNGHGEVLSVIVHSQDSDKEDCEENDDGDAEGDLEN 296

Human    71 H------HRAPEHSLAGPLHPTMTMACE--TPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHH 127
            .      .|:.|..|:...:.|:|...:  :.||.|. |:|.||||:||||||||:|:||.:..|
  Fly   297 EDDDERDSRSREQLLSHSSYQTLTSVNDRLSSPGFSQ-TSYATLTPIQPLPPISTMSEKFAYSGH 360

Human   128 HHHHHHHPHHHQRLAGNVSGSFTLMRDERG----------------------------------- 157
                         ::|..||...:..|..|
  Fly   361 -------------ISGGDSGDTDVNGDGAGGGVVEVGEVTNQSSEATGTVSISSGNATSSVCSNN 412

Human   158 -LASMNNLYTPYHKDVAGMG-----QS-----------LSP-------------------LSSSG 186
             .:|.:.|..|......|:|     ||           :||                   ::||.
  Fly   413 DCSSFSALSMPIGSGHLGLGVLSGVQSPFSSYEKLSSMISPPPNNYLVSCDLHSSVSGRVINSSH 477

Human   187 LGSIHN---SQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGR-------------------- 228
            |...||   .:.|...:.|    .|.|    .||.:..:...:.|
  Fly   478 LQLSHNGNKKESGTHEHTH----RPAD----VNGGKFSYTGHISRGDSVDNDVNGEKFSFSDHIS 534

Human   229 --------------------------------------HGE------------------------ 231
                                                  |.|
  Fly   535 GGDSGDEDANREKFIYSDHISEGENGPDVNSGTNWLQMHSEREVRLHMPVPAELEARFHISSERR 599

Human   232 -------------QHLTP----------------TSAGMVPIN-------GLPPHHP-------- 252
                         :||.|                ::||:|.:.       .|.|..|
  Fly   600 TRLNVPPARGSLSRHLAPNAPICPADWKADDWKHSNAGVVSLTADMPVVVSLTPTPPPLRDDSVS 664

Human   253 ---HAHLNAQGHGQ--LLGTAREP-------------------------NPSVTG---------- 277
               ....::.||.:  .|..::||                         :||..|
  Fly   665 GIKQNERSSPGHREQYFLDKSQEPSSVVADQCSPGINGTPQSVCVIHQQSPSALGNGFQSSSQQA 729

Human   278 ---------AQVSNG-------SNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGT 326
                     ..||:|       :||..|||||||::||||:.|||||||||||||||||||||||
  Fly   730 KVSSCASPKGTVSSGGAVSNRIANSSDMEEINTKDLAQRISAELKRYSIPQAIFAQRVLCRSQGT 794

Human   327 LSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAA---------------------- 369
            ||||||||||||||||||||||||:|||||||||||||||:||
  Fly   795 LSDLLRNPKPWSKLKSGRETFRRMYKWLQEPEFQRMSALRMAAAQIPQRAPLSSGMSLGSATGPS 859

Human   370 ----------------------------------------------CKRKEQEHGKDRGNTPKKP 388
                                                          |:||| |...::...||||
  Fly   860 GSTGTIPTDLDPHGGPTMIQNPLTNESDSSPASTPVTSVLVGSVVSCRRKE-EPQIEQMPQPKKP 923

Human   389 RLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNS 452
            ||||||:|||||.|||||.||||||:|:||::|||||.:||.||||||||||:|||:|:.|.::
  Fly   924 RLVFTDLQRRTLQAIFKETKRPSKEMQVTIARQLGLEPTTVGNFFMNARRRSMDKWRDDDSKST 987

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ONECUT1	NP_004489.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..55		10/37 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..141		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..290		11/76 (14%)
		CUT	288..362	CDD:460543	67/73 (92%)
		HOX	385..440	CDD:197696	44/54 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..465		5/11 (45%)
onecut	NP_524842.2	CUT	756..830	CDD:460543	67/73 (92%)
		HOX	920..975	CDD:197696	44/54 (81%)