DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GIIIspla2 and PLA2G3

DIOPT Version :9

Sequence 1:	NP_001285008.1	Gene:	GIIIspla2 / 31747	FlyBaseID:	FBgn0030013	Length:	217	Species:	Drosophila melanogaster
Sequence 2:	NP_056530.2	Gene:	PLA2G3 / 50487	HGNCID:	17934	Length:	509	Species:	Homo sapiens

Alignment Length:	166	Identity:	61/166 - (36%)
Similarity:	86/166 - (51%)	Gaps:	15/166 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PGTDAKHLAIRLRDPQSEIES----ETVPLAHVHSHSHTDESGVRGAAAVHRRERRQLSDWLIAP 87
            ||.:.:.....|   ||:.|:    |..| |.........:|||.|..  |:||:|   .|.: |
Human   100 PGPELQRALATL---QSQWEACRALEESP-AGARKKRAAGQSGVPGGG--HQREKR---GWTM-P 154

  Fly    88 NTRWCGRGNLANGTYNDLGGASKADKCCRKHDHCKMWIDGMSNRYDLFNYRPYTLSHCSCDLRFR 152
            .|.|||.|:.| |..::||.....|.|||:||.|...|..:...|.:.|||.:|:|||.||.||:
Human   155 GTLWCGVGDSA-GNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQ 218

  Fly   153 TCLKMAGDEDANAIGKLFFNVVQTQCFGLKAETVCV 188
            .||:...|..::.:|..||||::..||.|:.:..||
Human   219 QCLQNQHDSISDIVGVAFFNVLEIPCFVLEEQEACV 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GIIIspla2	NP_001285008.1	PLA2_bee_venom_like	84..181	CDD:153093	40/96 (42%)
PLA2G3	NP_056530.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..149		9/28 (32%)
		Phospholipase A2-like. /evidence=ECO:0000269\|PubMed:12522102, ECO:0000269\|PubMed:15863501, ECO:0000269\|PubMed:17868035	150..291		44/107 (41%)
		PLA2_bee_venom_like	151..247	CDD:153093	41/97 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..354
		PLA2_group_III_like	314..427	CDD:153094
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145872
Domainoid	1	1.000	92	1.000	Domainoid score	I7600
eggNOG	1	0.900	-	-		E1_28MF1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8069
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003412
OrthoInspector	1	1.000	-	-		otm40907
orthoMCL	1	0.900	-	-		OOG6_116629
Panther	1	1.100	-	-	O	PTHR12253
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5827
SonicParanoid	1	1.000	-	-		X3866
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.680