DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf6 and TRAF6

DIOPT Version :9

Sequence 1:	NP_511080.2	Gene:	Traf6 / 31746	FlyBaseID:	FBgn0265464	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_004611.1	Gene:	TRAF6 / 7189	HGNCID:	12036	Length:	522	Species:	Homo sapiens

Alignment Length:	535	Identity:	142/535 - (26%)
Similarity:	226/535 - (42%)	Gaps:	167/535 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 IAASSSA-TPSAAAGGGASGAPTPPKSLALNQNHHYAPGSDTSGEQEE---------ELLDSRYE 103
            :|:|.|| |...:.||.||                  .|:.:|...||         ..|:|:||
Human    23 MASSCSAVTKDDSVGGTAS------------------TGNLSSSFMEEIQGYDVEFDPPLESKYE 69

  Fly   104 CAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLSAEHDIFPDNYTRREIEQLKRD 168
            |.||:..|.|.|.|.||||||::|:...::.....||:||:.| .|:.:||||:.:|||..|...
Human    70 CPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEIL-LENQLFPDNFAKREILSLMVK 133

  Fly   169 CPNSSLGCSVVASPIELH----RHL--------------PSC--PY--------------RRQ-- 197
            |||.  ||        ||    |||              |.|  |:              |||
Human   134 CPNE--GC--------LHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVS 188

  Fly   198 ------------QEPQEEKCPFAKIKCDFVG--------------------------------RP 218
                        :|..::.||.|.:.|::..                                :.
Human   189 CDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKM 253

  Fly   219 ETNQLEEHLKADMPHHMQLMLQAFQQTAIATWQPHKPSTSGAAVENGHGQQQLPPPPQYANGVDE 283
            :.|.|..||:.:...||:::.||....::.                        |...|.:.| .
Human   254 QRNHLARHLQENTQSHMRMLAQAVHSLSVI------------------------PDSGYISEV-R 293

  Fly   284 QIVQTMYQ---RIVVLEQRTREQETRLE-------NMQKQLR-LARQQAPVDPRYSNGTIVWRIE 337
            ...:|::|   |:|..:.:.||...::|       .:::.:| |..:.|.::.:..||..:|:|.
Human   294 NFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIG 358

  Fly   338 QLGALVARLRANANNQ---VYSHECYTSPHGYKFCARLNIQ----PRKPHVLSLHVHLMQSENDY 395
            ..|   ..|:.....:   ::|...||...|||.|.||::|    .|..:.:||.||.||.|.|.
Human   359 NFG---MHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS 420

  Fly   396 HLDWPFKGRIKLCMVHPADATLSQ-HDTIM-TKPEILAFHKPREAISTRGFGFLEYANISNIIQL 458
            ||.|||:|.|:|.::..::|.:.| |:.|| .|||:|||.:|....:.:|||::.:.::..:.|.
Human   421 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQR 485

  Fly   459 GFCADDRLLIKIEIN 473
            .|..||.||::.|::
Human   486 TFIKDDTLLVRCEVS 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	16/37 (43%)
		Sina	163..>230	CDD:302762	26/146 (18%)
		MATH_TRAF6	330..473	CDD:239745	54/151 (36%)
TRAF6	NP_004611.1	Interaction with TAX1BP1. /evidence=ECO:0000269\|PubMed:10920205	1..354		89/384 (23%)
		RING	69..107	CDD:238093	16/37 (43%)
		zf-TRAF	204..261	CDD:280357	6/56 (11%)
		MATH_TRAF6	351..500	CDD:239745	54/151 (36%)
		Interaction with TANK. /evidence=ECO:0000269\|PubMed:25861989	355..522		53/149 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149519
Domainoid	1	1.000	104	1.000	Domainoid score	I6741
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3395
Inparanoid	1	1.050	166	1.000	Inparanoid score	I4182
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50043
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	1	1.000	-	-		FOG0008003
OrthoInspector	1	1.000	-	-		oto91588
orthoMCL	1	0.900	-	-		OOG6_109516
Panther	1	1.100	-	-	LDO	PTHR10131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5828
SonicParanoid	1	1.000	-	-		X5961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800