Protein Alignment Traf6 and TRAF5

DIOPT Version :9

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: XP_011508259.1
• Gene: TRAF5 / 7188
• HGNCID: 12035
• Length: 631
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 134/632 - (21%)
• Similarity: 224/632 - (35%)
• Gaps: 203/632 - (32%)

  Fly    39 MTTNLSS----------------TGRIAASSSATP------------SAAAGGGASGAPTPPKSL 75
            ||.:.||                :.|..|...|:|            :||......||..|..::
Human     1 MTVSASSRPLPARPLFPCARPRPSARAPAPPQASPPLRRRRRPQPGAAAAPADRPRGARAPSPTM 65

  Fly    76 ALNQNHHYAP--------GSDTSGEQEE-------ELLDSRYECAICIDWLNEPVLTSCGHRFCR 125
            |.::.|...|        |:..|.:.|.       |.|:.||:||.|...|:.|..|.||||||:
Human    66 AYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQ 130

  Fly   126 SCLTAWMQKNN-QCCPMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSV----------V 179
            .|:.:..:.|. ..||:| |.:....::|.||..:||:..|...|.|:. ||:.          :
Human   131 HCILSLRELNTVPICPVD-KEVIKSQEVFKDNCCKREVLNLYVYCSNAP-GCNAKVILGRYQVPL 193

  Fly   180 ASPIELHRHLPSCPYRRQQ-------EPQEEK---------CPFAKIKCDFVGR----------- 217
            |....|..||..|.::..|       ||...|         |.|.|.||.:..:
Human   194 ACCYLLQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHE 258

  Fly   218 -------------------------------PETNQ-----------------LEEHLKADMPHH 234
                                           ||..|                 |::|..:.:..|
Human   259 ENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREH 323

  Fly   235 MQLMLQAFQQTAIATWQPHKP-----------------------------STSGAAVEN-----G 265
            |:|:|:...|........||.                             ..:|:.:.|     .
Human   324 MRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFAS 388

  Fly   266 H------------------GQQQ----LPPPPQYANGVDEQI--VQTMYQRIVVLEQRTREQETR 306
            |                  .|||    |.|..:..:.|.::|  ::...||:.|||:.|.:.:|.
Human   389 HIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTH 453

  Fly   307 LENMQKQLRLARQQAP-VDPRYSNGTIVWRIEQLGALVARLRANANNQVYSHECYTSPHGYKFCA 370
            :...:.||....::.. ::....||.::|::.................::|...|||..||:.||
Human   454 INIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCA 518

  Fly   371 RLNI----QPRKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQH--DTIMTKPEI 429
            |..:    ..|..| |||:..:|:.|.|..|.|||:.|:.|.::   |.:..::  :|....|..
Human   519 RAYLNGDGSGRGSH-LSLYFVVMRGEFDSLLQWPFRQRVTLMLL---DQSGKKNIMETFKPDPNS 579

  Fly   430 LAFHKP--REAISTRGFGFLEYANISNIIQLGFCADDRLLIKIEINI 474
            .:|.:|  ...|::....|:.::.:.| .:..:..||.|.:|:.:::
Human   580 SSFKRPDGEMNIASGCPRFVAHSVLEN-AKNAYIKDDTLFLKVAVDL 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	15/38 (39%)
		Sina	163..>230	CDD:302762	24/151 (16%)
		MATH_TRAF6	330..473	CDD:239745	37/150 (25%)
TRAF5	XP_011508259.1	RING	109..145	CDD:214546	14/35 (40%)
		zf-TRAF	202..257	CDD:280357	12/54 (22%)
		zf-TRAF	257..315	CDD:280357	4/57 (7%)
		MATH	478..624	CDD:295307	37/150 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820