Protein Alignment Traf6 and TRAF3

DIOPT Version :9

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_003291.2
• Gene: TRAF3 / 7187
• HGNCID: 12033
• Length: 568
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 109/570 - (19%)
• Similarity: 197/570 - (34%)
• Gaps: 192/570 - (33%)

  Fly    71 PPKSLALNQNHH---YAPGSDTSGEQEEELLDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWM 132
            ||..|..:::..   :.|......|:..:.::.:|:|..|...|..|..|.||||||.||:.|.:
Human    17 PPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALL 81

  Fly   133 QKNNQCCPMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCS--VVASPIELH-------RH 188
            ..::..|....:.: .:..:|.||..:|||..|:..|.|.|.||:  ::...:.:|       ..
Human    82 SSSSPKCTACQESI-VKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEE 145

  Fly   189 LP---------------------SCPYRRQ--------------QEPQEEKCPFAKIKCDFVGRP 218
            ||                     :|.||..              |:.::..||...:.|     |
Human   146 LPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSC-----P 205

  Fly   219 ETNQLEEHLKADMPHHMQLMLQA------------FQQTAIATWQPHKPSTSGAAVENGHGQQQL 271
            ....::..|::::..|:...:.|            ||    .|.|..|...:.:||      |.:
Human   206 HKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQ----GTNQQIKAHEASSAV------QHV 260

  Fly   272 PPPPQYANGVDEQI-------------VQTMYQRIVVLE---QRTRE------------------ 302
            ....:::|.:::::             :|:::.:|...|   :|.:|
Human   261 NLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDS 325

  Fly   303 QETRLENMQKQLRLARQQ----------------------------------------------- 320
            |..:|:.:.|::|..||.
Human   326 QAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQ 390

  Fly   321 ---------APVDPRYS-------NGTIVWRIEQLGALVARLRANANNQVYSHECYTSPHGYKFC 369
                     |.:|.|:.       ||.::|:|.................:||...||...|||.|
Human   391 MLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMC 455

  Fly   370 ARLNI----QPRKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEIL 430
            ||:.:    ..:..| |||...:|:.|.|..|.||||.::.|.::....:.....|.....|...
Human   456 ARVYLNGDGMGKGTH-LSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSS 519

  Fly   431 AFHKPREAISTRGFGFLEYAN------ISNIIQLG-FCADDRLLIKIEIN 473
            :|.||.        |.:..|:      ...:::.| :..||.:.||:.::
Human   520 SFKKPT--------GEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVD 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	15/37 (41%)
		Sina	163..>230	CDD:302762	18/110 (16%)
		MATH_TRAF6	330..473	CDD:239745	38/153 (25%)
TRAF3	NP_003291.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		3/10 (30%)
		zf-C3HC4	56..91	CDD:278524	14/34 (41%)
		zf-TRAF	136..192	CDD:280357	7/55 (13%)
		zf-TRAF	197..247	CDD:280357	10/58 (17%)
		BBP1_C	<263..>321	CDD:291921	6/57 (11%)
		Spc29	<307..>366	CDD:293687	7/58 (12%)
		MATH_TRAF3	378..563	CDD:239746	42/193 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820