Protein Alignment Traf6 and TRAF2

DIOPT Version :9

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_066961.2
• Gene: TRAF2 / 7186
• HGNCID: 12032
• Length: 501
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 113/548 - (20%)
• Similarity: 189/548 - (34%)
• Gaps: 189/548 - (34%)

  Fly    65 ASGAPTPPKSLALNQNHHYAPGSDTS--GEQEEELLDSRYECAICIDWLNEPVLTSCGHRFCRSC 127
            |:.:.|||.||.|.|     ||...:  |.:    |:::|.|:.|.:.|..|....||||:|..|
Human     2 AAASVTPPGSLELLQ-----PGFSKTLLGTK----LEAKYLCSACRNVLRRPFQAQCGHRYCSFC 57

  Fly   128 LTAWMQKNNQCCPM--------DNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCS------- 177
            |.:.:....|.|..        :...:......||||..|||:|.|...||:.  ||:
Human    58 LASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSD--GCTWKGTLKE 120

  Fly   178 ------------VVASPI--------ELHRHLP-SCPYR-------------RQQEPQEEKCPFA 208
                        :...|.        |..|||. .||.|             ...:...|.||..
Human   121 YESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKF 185

  Fly   209 KIKCDFVGRP----------------------------------------ETNQLEEHLK----- 228
            .:.||..|:.                                        |...|.|||.
Human   186 PLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSS 250

  Fly   229 --------ADMPHHMQLMLQAFQ----QTA-------IATWQPHKPSTSGAAVENGHGQQQLPPP 274
                    .|..|....:||..:    :||       :...:..:.:.:..|....|
Human   251 VLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQH-------- 307

  Fly   275 PQYANGVDEQIVQTMYQRIVVLEQRTREQETRLENMQKQLRLARQQAPVDPRYSNGTIVWRIEQL 339
                 .:|:..::.:..::..||:....::..:.:::::: |..:.:..|     |..:|:|...
Human   308 -----RLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKV-LEMEASTYD-----GVFIWKISDF 361

  Fly   340 G-----ALVARLRANANNQVYSHECYTSPHGYKFCARLNIQ----PRKPHVLSLHVHLMQSENDY 395
            .     |:..|:.|     ::|...|||.:|||.|.|:.:.    .|..| |||...:|:..||.
Human   362 ARKRQEAVAGRIPA-----IFSPAFYTSRYGYKMCLRIYLNGDGTGRGTH-LSLFFVVMKGPNDA 420

  Fly   396 HLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEIL--AFHKPREAISTRGFGFLEYANISNIIQL 458
            .|.|||..::.|.::   |....:|.....:|::.  :|.:|           :...||::...|
Human   421 LLRWPFNQKVTLMLL---DQNNREHVIDAFRPDVTSSSFQRP-----------VNDMNIASGCPL 471

  Fly   459 GFC------------ADDRLLIKIEINI 474
             ||            .||.:.||..:::
Human   472 -FCPVSKMEAKNSYVRDDAIFIKAIVDL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	13/37 (35%)
		Sina	163..>230	CDD:302762	25/160 (16%)
		MATH_TRAF6	330..473	CDD:239745	42/165 (25%)
TRAF2	NP_066961.2	RAD18	28..>157	CDD:333230	33/130 (25%)
		RING-HC_TRAF2	32..73	CDD:319553	14/40 (35%)
		RING-HC finger (C3HC4-type)	34..72	CDD:319553	13/37 (35%)
		zf-TRAF	178..235	CDD:280357	6/56 (11%)
		TRAF_BIRC3_bd	267..329	CDD:318808	9/74 (12%)
		Important for interaction with BIRC2 and BIRC3. /evidence=ECO:0000250	283..293		0/9 (0%)
		MATH_TRAF2	334..497	CDD:239747	44/189 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820