Protein Alignment Traf6 and TRAF1

DIOPT Version :9

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_001177874.1
• Gene: TRAF1 / 7185
• HGNCID: 12031
• Length: 416
• Species: Homo sapiens
• Alignment Length: 460
• Identity: 87/460 - (18%)
• Similarity: 157/460 - (34%)
• Gaps: 169/460 - (36%)

  Fly    60 AAGGGASGAPTPPKSLALNQNHHYAPGSDTSGEQEEELLDSRYECAICIDWLNEPVLTSCGHRFC 124
            |:..|:|..|.|.:    |:.....|.:.....:|..        |:|                |
Human     2 ASSSGSSPRPAPDE----NEFPFGCPPTVCQDPKEPR--------ALC----------------C 38

  Fly   125 RSCLTAWMQKNNQCCPMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHL 189
            ..||:            :|.| :.|..|.|    :...|.|:...|.|.|
Human    39 AGCLS------------ENPR-NGEDQICP----KCRGEDLQSISPGSRL--------------- 71

  Fly   190 PSCPYRRQQEPQEE------KCPFAKIKCDFVGRPETNQLEEHLKADMPHHMQLMLQAFQQTAIA 248
                 |.|::...|      .||||.:.|.|.|.|::  ::||.......|:.|:|...:|
Human    72 -----RTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQS--VQEHEVTSQTSHLNLLLGFMKQ---- 125

  Fly   249 TWQPHKPSTSGAAVENG---------------------------------HGQQQLP-------- 272
             |:    :..|..:|:|                                 ..|::|.
Human   126 -WK----ARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEK 185

  Fly   273 ------------------------------PPPQYANGVDEQIVQTMYQRIVVLEQRTREQETRL 307
                                          ....:.:.:|.:.:.::.||:|.|:|...:::..|
Human   186 LLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQAL 250

  Fly   308 ENMQKQLRLARQQAPVDPRYSNGTIVWRIEQLGALVARLRANANNQVYSHECYTSPHGYKFCARL 372
            ..:::.||| .::|..|     ||.:|:|..:..............::|...||:.:|||.|.||
Human   251 GKLEQSLRL-MEEASFD-----GTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRL 309

  Fly   373 NIQ----PRKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEI--LA 431
            .:.    .::.| |||.:.:|:.|.|..|.|||:.::...::   |....:|.....:|::  .:
Human   310 YLNGDGTGKRTH-LSLFIVIMRGEYDALLPWPFRNKVTFMLL---DQNNREHAIDAFRPDLSSAS 370

  Fly   432 FHKPR 436
            |.:|:
Human   371 FQRPQ 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	5/37 (14%)
		Sina	163..>230	CDD:302762	18/72 (25%)
		MATH_TRAF6	330..473	CDD:239745	29/113 (26%)
TRAF1	NP_001177874.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		6/25 (24%)
		SMC_N	<140..>263	CDD:330553	12/123 (10%)
		TRAF_BIRC3_bd	184..244	CDD:318808	6/59 (10%)
		MATH_TRAF1	267..413	CDD:239748	29/113 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820