DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf6 and lnx2b

DIOPT Version :9

Sequence 1:	NP_511080.2	Gene:	Traf6 / 31746	FlyBaseID:	FBgn0265464	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	315	Identity:	73/315 - (23%)
Similarity:	122/315 - (38%)	Gaps:	59/315 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 GSDTSGEQEEELLDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLSAEH 150
            |.|:...:.::.:|....|.||:..|.:|:.|.|||.:|..||:.::. :...||:|.:|:..:.
Zfish    28 GQDSHLFEYQDEVDDELVCHICLQPLLQPMDTPCGHTYCFQCLSNFLH-DQDFCPVDRQRIQLQQ 91

  Fly   151 DIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPS-CP-YRRQQEPQEEKCPFAKIKCD 213
            ........|..:::|...||..| .|.:.....||..||.: || ::|.:|..|.|
Zfish    92 CRASSLLVRNLLDKLAVLCPFRS-ECELSMQRCELQPHLHNRCPAFKRLREEAERK--------- 146

  Fly   214 FVGRPETNQLEEHLKADMPHHMQLMLQAFQQTAIATWQPHKPSTSGAAVENGHGQQQLPPPPQYA 278
              .||..|:|:.. |:|.........|...:||..: .|.:|.....|.|.|...     .|...
Zfish   147 --KRPSWNELKGS-KSDGDLADAKSAQTIGRTAQLS-APSEPGLVNPAFEEGEDD-----TPLRC 202

  Fly   279 NGVDEQIVQTMYQ---------RIVVLEQRTREQETRLENMQKQLRLARQQAPVDPRYSNGTIVW 334
            :.|.|..|..:::         |||      ..::|.|.|:..|..:.......|.:.:.|..:.
Zfish   203 SLVAEATVVELFREDPGEDLGLRIV------GGKDTPLGNIVIQEIVRDSLVARDGKLAPGDHIL 261

  Fly   335 RIEQLG-ALVARLRANANNQVYSHECYTSPHGYKFCARLNI--------QPRKPH 380
            .:..:. |.::..||.|        ....|     |:||.:        :||..|
Zfish   262 EVNDVSLASISHSRAIA--------VIRQP-----CSRLRLTVMQEKGFKPRPEH 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	13/37 (35%)
		Sina	163..>230	CDD:302762	20/68 (29%)
		MATH_TRAF6	330..473	CDD:239745	12/60 (20%)
lnx2b	NP_998105.2	RING	46..82	CDD:214546	13/36 (36%)
		PDZ_signaling	210..291	CDD:238492	18/99 (18%)
		PDZ_signaling	325..406	CDD:238492
		PDZ_signaling	451..537	CDD:238492
		PDZ_signaling	587..671	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810