Protein Alignment Traf6 and traf3

DIOPT Version :10

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_001003513.1
• Gene: traf3 / 445119
• ZFINID: ZDB-GENE-040801-257
• Length: 573
• Species: Danio rerio
• Alignment Length: 562
• Identity: 118/562 - (20%)
• Similarity: 184/562 - (32%)
• Gaps: 172/562 - (30%)

  Fly    72 PKSLA---LNQNHHYAPG-SDTSGEQEEELL---DSRYECAICIDWLNEPVLTSCGHRFCRSCLT 129
            |.|||   :.|.....|| |...|...:..:   :.:|.|..|...|..|..|.||||||.||:.
Zfish    17 PPSLAMPSMAQRPRPEPGFSPLHGGFRDHFVTTPEPKYCCETCRLVLCNPRQTECGHRFCESCIN 81

  Fly   130 AWMQKNNQCCPMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPY 194
            ..:.|.|..||.|...| .|..||.|....|||..||..|.:...||.......::..||..|||
Zfish    82 ELLSKPNPVCPADLLPL-FEDKIFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVMEHLVICPY 145

  Fly   195 ----------------------------------------------------------------- 194
                                                                             
Zfish   146 FEVPCPLGKCKEKMMRKDMPEHLSRKCKHREVTCEFCSLKMALTELQKHKETVCPAFPVACPNHC 210

  Fly   195 ------RRQQEPQEEKCPFAKIKCDFVG-----RPETNQLEEHLKADMPHHMQLMLQAFQQTAIA 248
                  |.:....:..||.|::.|.|:.     :....::.||..:....|:::|  |.:.|.:.
Zfish   211 SFSSILRSELSSHQHDCPKAQVTCSFIRYGCSYKGLNQEMREHESSFASEHLRMM--AVRNTTLE 273

  Fly   249 T---------WQPHK--PSTSGAAVE-----------NGHGQQQLPPPPQYANGVDEQI--VQTM 289
            .         .:.:|  ||.|....|           |...:|:|.......:...|::  |:..
Zfish   274 AKVEDVKSELMERYKVLPSLSSRLAEVERQYEEMREKNRQLEQKLVSMQMLMSSHSEKLLEVEME 338

  Fly   290 YQRIVVLEQRTREQET---------------------------RLENMQKQL------------R 315
            .:.:..|.....|.||                           .|.::::||            |
Zfish   339 LRELRPLRAMREEVETLRGSVESMRSMVSSLDSSCVNSASGSHTLASLEQQLTRHDDLMSVHDVR 403

  Fly   316 LARQQAP---VDPRYSNGTIVWRIEQLGALVARLRANANNQVYSHECYTSPHGYKFCARLNI--- 374
            ||.....   ::....|||::|:|............:....:||...||...|||.|||:.:
Zfish   404 LAEMDLKLQVLETASFNGTLIWKIRDYKRRKQEAVVSKTLSLYSQPFYTGYFGYKMCARVYLNGD 468

  Fly   375 -QPRKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEILAFHKPREA 438
             ..:..| |||...:|:.|.|..|.||||.::.|.::....|.....|.....|...:|.:|.
Zfish   469 GMGKGTH-LSLFFVVMRGEYDALLQWPFKQKVTLMLMDQGPARKHLGDAFKPDPSSSSFRRPT-- 530

  Fly   439 ISTRGFGFLEYAN------ISNIIQLG-FCADDRLLIKIEIN 473
                  |.:..|:      ...:::.| :..||.:.||:.::
Zfish   531 ------GEMNIASGCPLFVAQTVLENGTYIKDDTIFIKVTVD 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	mRING-HC-C3HC3D_LNX1-like	101..143	CDD:438299	18/41 (44%)
		Sina	169..>230	CDD:460824	16/136 (12%)
		MATH_TRAF6	330..473	CDD:239745	39/153 (25%)
traf3	NP_001003513.1	RING-HC_TRAF3	54..95	CDD:438302	18/40 (45%)
		cdk7	70..>123	CDD:129661	24/53 (45%)
		zf-TRAF	139..194	CDD:280357	5/54 (9%)
		zf-TRAF	198..253	CDD:280357	6/54 (11%)
		COG4372	256..>435	CDD:443500	29/180 (16%)
		MATH_TRAF3	383..568	CDD:239746	46/193 (24%)