DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf6 and traf4a

DIOPT Version :9

Sequence 1:	NP_511080.2	Gene:	Traf6 / 31746	FlyBaseID:	FBgn0265464	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_991325.1	Gene:	traf4a / 404045	ZFINID:	ZDB-GENE-040308-1	Length:	470	Species:	Danio rerio

Alignment Length:	466	Identity:	103/466 - (22%)
Similarity:	178/466 - (38%)	Gaps:	108/466 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 RYECAICIDWLNEPV-LTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLSAEHDIFPDNYTRREIEQ 164
            |::|.:|...:.||| :::||||||.:||..::.:....||.|...|... .|:||....::|..
Zfish    15 RFQCPLCSKAMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYA-KIYPDPELEQQILA 78

  Fly   165 LKRDCPNSSLGCSVVASPIELHRHLPSCPYR-------------RQQEPQ--EEKCPFAKIKCDF 214
            |...|.:|..||.......:|..|..:|.:.             |:..|:  :..||..|:||:|
Zfish    79 LPIRCIHSEEGCRWTGQMKQLQSHFSTCAFNVIPCPNRCSVKLTRRDLPEHLQHDCPKRKVKCEF 143

  Fly   215 VGRPETNQ----------------------------LEEHLKADMPHHMQLMLQAFQQTAIATWQ 251
            .|...|.:                            |.:|...:.|...|......::....|.|
Zfish   144 CGSEFTGEAYENHQGICPQESVYCENKCGARMMRRLLSQHTMTECPKRTQPCKYCGKEFVYDTIQ 208

  Fly   252 PHK----------PSTSGAA----------VENGHGQQQLPPP----------PQYANGVDEQIV 286
            .|:          |:..|..          |:...|...:..|          |:.|.|..
Zfish   209 NHQYHCPRFPVQCPNQCGTPNIAREDLANHVKESCGSALVLCPFKEAGCKHRCPKMAIGRH---- 269

  Fly   287 QTMYQRIVVLEQRTREQETRL-----ENMQKQLRLARQQAPVDPRYSNGTIVWRIEQLGALVARL 346
                     ||:.|:...|.:     ...|:.|.|.|:...:...: :|.::|::......:...
Zfish   270 ---------LEESTKSHLTMMCSLVGRQRQEILELRREMEELSVSH-DGVLIWKLTDYSRKLQEA 324

  Fly   347 RANANNQVYSHECYTSPHGYKFCARL----NIQPRKPHVLSLHVHLMQSENDYHLDWPFKGRIKL 407
            :...|::.:|...||..:|||.....    |......| ||:::.::..|.|..|:|||..::..
Zfish   325 KLRNNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSH-LSIYIRVLPGEYDNLLEWPFSYKVTF 388

  Fly   408 CMVHPADATLS--QH--DTIMTKPEILAFHKP---REAI--STRGFGFLEYANISNIIQLGFCAD 463
            .::..:|.:||  ||  :|....|....|.||   |.::  ||.|||:.::.:...|.:..:..|
Zfish   389 SILDQSDPSLSKPQHITETFNPDPNWKNFQKPCSSRNSLDESTLGFGYPKFISHEEIKKRNYIRD 453

  Fly   464 DRLLIKIEINI 474
            :.:.:|..|.|
Zfish   454 NSIFLKASIEI 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	14/38 (37%)
		Sina	163..>230	CDD:302762	20/109 (18%)
		MATH_TRAF6	330..473	CDD:239745	38/155 (25%)
traf4a	NP_991325.1	RING	17..55	CDD:238093	13/37 (35%)
		zf-TRAF	102..156	CDD:280357	12/53 (23%)
		zf-TRAF	156..210	CDD:280357	6/53 (11%)
		zf-TRAF	210..269	CDD:280357	9/58 (16%)
		MATH_TRAF4	308..463	CDD:239750	38/155 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820