Protein Alignment Traf6 and Traf6

DIOPT Version :9

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_001290202.1
• Gene: Traf6 / 22034
• MGIID: 108072
• Length: 530
• Species: Mus musculus
• Alignment Length: 533
• Identity: 140/533 - (26%)
• Similarity: 235/533 - (44%)
• Gaps: 128/533 - (24%)

  Fly    37 NEMTTNLSSTGRIAASSSATPSAAAGGGASGAPTPPKSLALNQNHHYAPGSDTSGEQEEEL---- 97
            |...::.||:...||.:::..:|......||:               |...:.|....||:
Mouse     8 NSCGSSQSSSDCCAAMAASCSAAVKDDSVSGS---------------ASTGNLSSSFMEEIQGYD 57

  Fly    98 ------LDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLSAEHDIFPDN 156
                  |:|:|||.||:..|.|.|.|.||||||::|:...::.....||:||:.| .|:.:||||
Mouse    58 VEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEIL-LENQLFPDN 121

  Fly   157 YTRREIEQLKRDCPNSSLGC------------------SVVASP--------IELHRH-LPSCPY 194
            :.:|||..|...|||.  ||                  ::|..|        .:::.| :..||.
Mouse   122 FAKREILSLTVKCPNK--GCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPR 184

  Fly   195 RR-------------QQEPQEEKCPFAKIKCDFVG------------------------------ 216
            |:             ::|..::.||.|.|.|::.|
Mouse   185 RQVSCVNCAVSMAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGC 249

  Fly   217 --RPETNQLEEHLKADMPHHMQLMLQAFQQTAIATWQPHKPSTSGAAVENGHGQQQLPPPPQYAN 279
              :.:.|.|..||:.:...||:|:.||.....:|.    :|..   |.....|.:  |..|.|
Mouse   250 HEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLAL----RPCD---AASPSRGCR--PEDPNY-- 303

  Fly   280 GVDEQIVQTMYQRIVVLEQRTREQETRLE-------NMQKQLR-LARQQAPVDPRYSNGTIVWRI 336
               |:.::.:..|:|..:.:.||...::|       .:::.:| |..:.|.::.:..||..:|:|
Mouse   304 ---EETIKQLESRLVRQDHQIRELTAKMETQSMYVGELKRTIRTLEDKVAEMEAQQCNGIYIWKI 365

  Fly   337 EQLGALVARLRANANNQVYSHECYTSPHGYKFCARLNIQ----PRKPHVLSLHVHLMQSENDYHL 397
            ...|..:..........::|...||...|||.|.||::|    .|..:.:||.||.||.|.|.||
Mouse   366 GNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHL 430

  Fly   398 DWPFKGRIKLCMVHPADATLSQ-HDTIM-TKPEILAFHKPREAISTRGFGFLEYANISNIIQLGF 460
            .|||:|.|:|.::..::|.:.| |:.:| .|||:|||.:|....:.:|||::.:.::..:.|..|
Mouse   431 PWPFQGTIRLTILDQSEALIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTF 495

  Fly   461 CADDRLLIKIEIN 473
            ..||.||::.|::
Mouse   496 IKDDTLLVRCEVS 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	16/37 (43%)
		Sina	163..>230	CDD:302762	23/138 (17%)
		MATH_TRAF6	330..473	CDD:239745	52/148 (35%)
Traf6	NP_001290202.1	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		108/447 (24%)
		RING	69..107	CDD:238093	18/37 (49%)
		zf-TRAF	204..261	CDD:280357	13/56 (23%)
		SlyX	304..>356	CDD:294687	15/55 (27%)
		MATH_TRAF6	359..508	CDD:239745	33/88 (38%)
		Interaction with TANK. /evidence=ECO:0000250|UniProtKB:Q9Y4K3	363..530		31/84 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839575
Domainoid	1	1.000	108	1.000	Domainoid score	I6474
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3395
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4079
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50043
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	1	1.000	-	-		FOG0008003
OrthoInspector	1	1.000	-	-		oto95169
orthoMCL	1	0.900	-	-		OOG6_109516
Panther	1	1.100	-	-	LDO	PTHR10131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5828
SonicParanoid	1	1.000	-	-		X5961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800