Protein Alignment Traf6 and Traf5

DIOPT Version :9

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_035763.2
• Gene: Traf5 / 22033
• MGIID: 107548
• Length: 558
• Species: Mus musculus
• Alignment Length: 518
• Identity: 113/518 - (21%)
• Similarity: 192/518 - (37%)
• Gaps: 141/518 - (27%)

  Fly    96 ELLDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNN-QCCPMDNKRLSAEHDIFPDNYTR 159
            |.|:.||:||.|...|:.|..|.||||||:.|:.:..:.|: ..||:| |.:....::|.||..:
Mouse    37 EQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVD-KEVIKPQEVFKDNCCK 100

  Fly   160 REIEQLKRDCPNSS-------LG--------CSVVASPI------------ELHRHLPS-CPYRR 196
            ||:..|...|.|:.       ||        ||..|.|.            ::..||.: |.:|.
Mouse   101 REVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCPNESCREAMLRKDVKEHLSAYCRFRE 165

  Fly   197 Q--------------QEPQEEKCPFAKIKC-----DFVGR----------PETNQ---------- 222
            :              |:.:|..||...:.|     ..:.|          ||..|
Mouse   166 EKCLYCKRDIVVTNLQDHEENSCPAYPVSCPNRCVQTIPRARVNEHLTVCPEAEQDCPFKHYGCT 230

  Fly   223 -------LEEHLKADMPHHMQLML--------------QAFQQ---------------------- 244
                   |.||.:|.:..||.|:|              |:.:|
Mouse   231 VKGKRGNLLEHERAALQDHMLLVLEKNYQLEQRISDLYQSLEQKESKIQQLAETVKKFEKELKQF 295

  Fly   245 --------TAIATWQPHKPSTSGAAVENGHGQQQLPPPPQYANGVD------------EQIVQ-- 287
                    |.::..|.....|..:|......:|.|....|..:.:|            ::|.|
Mouse   296 TQMFGRNGTFLSNVQALTSHTDKSAWLEAQVRQLLQIVNQQPSRLDLRSLVDAVDSVKQRITQLE 360

  Fly   288 TMYQRIVVLEQRTREQETRLENMQKQLRLARQQ-APVDPRYSNGTIVWRIEQLGALVARLRANAN 351
            ...||:|:||..|.:.:..:...:.||....:: ..::....:|.::|::...............
Mouse   361 ASDQRLVLLEGETSKHDAHINIHKAQLNKNEERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHT 425

  Fly   352 NQVYSHECYTSPHGYKFCARLNIQ---PRKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPA 413
            ..|:|...|||..||:.|||..:.   ..|...|||:..:|:.|.|..|.|||:.|:.|.::..:
Mouse   426 VSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQS 490

  Fly   414 DATLSQHDTIMTKPEILAFHKP--REAISTRGFGFLEYANISNIIQLGFCADDRLLIKIEINI 474
            .......:|....|...:|.:|  ...|::....|:.::.:.| .:..:..||.|.:|:.:::
Mouse   491 GKKNHIVETFKADPNSSSFKRPDGEMNIASGCPRFVSHSTLEN-SKNTYIKDDTLFLKVAVDL 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	15/38 (39%)
		Sina	163..>230	CDD:302762	25/140 (18%)
		MATH_TRAF6	330..473	CDD:239745	36/147 (24%)
Traf5	NP_035763.2	mRING-HC-C3HC3D_TRAF5	43..85	CDD:319556	18/42 (43%)
		zf-TRAF	128..183	CDD:280357	9/54 (17%)
		zf-TRAF	185..241	CDD:424248	9/55 (16%)
		Smc	<237..>419	CDD:224117	30/181 (17%)
		Interaction with EIF2AK2/PKR. /evidence=ECO:0000250	345..558		46/209 (22%)
		MATH_TRAF5	404..551	CDD:239749	36/147 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910